December 2022 Flashcards
1
You are a general practitioner. A healthy woman in the 8th week of pregnancy is being tested for rubella
virus serology. She is a kindergarten teacher and there have been non-vaccinated children with rubella
in the kindergarten. Her blood sample is positive for rubella-IgG, but not for rubella-IgM antibodies.
What is the most appropriate advice and guidance you can give her?
A If she is exposed to rubella infection, she will not get sick herself, but there is a danger that the
fetus may get rubella.
B She should be revaccinated against rubella before returning to work in kindergarten
C She can go to work safely - neither the fetus nor herself is in danger of getting rubella
D If she is exposed to rubella infection, she and the fetus can get rubella
C. As she has IgG (but not IgM) antibodies, she has longstanding immunity to rubella, probably because of previous vaccination. Recent infection would give both IgG and IgM antibodies.
2
A mother comes with her 15-month-old daughter to the emergency service (“Legevakten”) where you
work as a junior doctor. The mother explains that this afternoon the girl had generalized convulsions in
both arms and legs lasting around 8 minutes. You interpret this description as tonic-clonic convulsions.
During the episode the girl was unconscious, and the parents got very scared.
Earlier today the girl had a runny nose, and a rectal temperature of 39.9 OC shortly before onset of
seizures.
The girl has never had convulsions/seizures before. However, her father has epilepsy.
On examination at the emergency service the child is awake, and in a good condition. There are
normal findings on the neurological examination.
What is the best classification of this episode?
A New onset childhood epilepsy – hereditary origin
B First time simple febrile seizures
C Meningitis-related seizures
D First time complex febrile seizures
B
The description of this seizure attack is in line with the definition of simple febrile seizures (duration shorter than 15 minutes, generalised seizure attack)
Simple febrile seizures
– Generalised seizure
– Duration < 15 min
– Occur once in a 24-h period
Complex febrile seizures
Defined by one of the following:
* Focal seizures
* Prolonged seizure attack (> 15 min)
* Multiple; occur more than once in a 24-h period
This is a provoked seizure attack with fever, and cannot at this stage be classified as epilepsy.
She has recovered and is in good condition on examination, so it was probably not meningitis.
Learning outcome: K4
3
You are a general practitioner. A father brings his 3-year-old son with history of a limp for two days with
quite sudden onset. No trauma. The boy’s general condition is reduced and he is not running around.
On examination you find reduced flexion and internal rotation in his right hip. He seems in obvious pain
when you examine the hip.
Rectal temperature 39.7 C OC.
C-reactive protein (CRP) 107 mg/L (Ref <5 mg/L).
Leukocytes 27,5 (Ref 4,4-12,5 x 10^9/L)
What is the most likely diagnosis?
A Calvé-Legg-Perthes disease
B Bacterial arthritis
C Juvenile idiopathic arthritis
D Coxitis simplex
B
Bacterial arthritis is most likely as he has general symptoms, pain and local symptoms (not weight-bearing) and raised leukocytes and CRP.
Coxitis simplex is less likely with high fever and high CRP. Juvenile idiopathic arthritis and Calvé -Legg-Perthes disease may start like this but usually don’t have this sudden onset.
Learning outcome: K4
4
Some children with epilepsy are treated with a diet. This diet has a well-documented effect and may
reduce seizure frequency in many patients.
What are the characteristics and effects of this diet?
A It is rich in aminoacids and suppresses seizures
B It is rich in carbohydrates and contributes with enough glucose
C It is rich in proteins and helps brain repair
D It is rich in fat and maintains ketosis
D
The ketogenic diet may be helpful for some patients with epilepsy. It is a diet predominantly rich in
fat and maintains long-term ketosis. High concentrations of ketone bodies have been correlated
with better seizure control. The mechanism of action is not entirely known, but ketone bodies
increase degradation of glutamate and increase the conversion of glutamine to inhibitory GABA
Learning outcome: K5
5
You are a junior doctor in the Department of Pediatrics. You are asked to see a baby in the Maternity
ward who was born 23 hours ago. It was an uncomplicated vaginal delivery at term. Birth weight 2890
g. Mother has started breastfeeding. The baby looks healthy, but is clearly jaundiced.
You check blood tests that show
* Baby: Total serum bilirubin 188 μmol/L. Direct anti-globuline (Coombs) test: positive. Blood type A
and Rh-D positive
* Mother: Blood type is O, Rh-D positive.
What is the most likely cause of jaundice (icterus) in this case?
A Breast milk induced jaundice
B Physiological jaundice
C Bile duct obstruction
D Immunization
D
Physiological jaundice is not correct when jaundice appaears that early, more common after 36-48 hours. Hemolytic disease is most likely due to blood group incompatibilities and immunization; in this case the mother has blood group O and the baby blood group A, and the
DAT test is positive indicating antibodies in the baby’s red blood cells.
Bile duct atresia uncommon, typically prolonged jaundice (high conj. bilirubin).
Breast milk induced in 15% of all healthy newborns, typically a diagnosis of exclusion if jaundice persists after 10-14 days of age.
Learning outcome: K3
6
A 5-year-old boy receives furosemide due to a severe cardiomyopathy and congestive heart failure.
What is the pharmacodynamic action of furosemide?
A Blocks the Na+ channels in the distal tubuli, and thereby inhibiting Na+ reabsorption
B Acts as an aldosterone antagonist with diuretic and antihypertensive effect
C Inhibits the Na+/Cl- co-transporter in the proximal part of the distal tubules
D Inhibits the Na+/K+/2Cl- co-transporter in the ascending part of Henle’s loop
D
Correct is that furosemide inhibits the Na+/K+/2Cl- co-transporter in the ascending part of Henle’s
loop; a loop diuretic
Learning outcome: K8
7
A 15-month-old boy comes to the community health center with his dad to have the measles-mumps-
rubella (MMR)-vaccine. The dad wants to know why the boy has to take all these three vaccines now,
since he received diphtheria, pertussis and tetanus vaccine only three months ago.
Why is childhood vaccination recommended for mumps, morbilli, diphtheria, measles?
A Mumps carries a risk for male infertility and hearing impairment
Morbilli carries a high risk for pregnant women of adverse pregnancy outcomes
Measles is a dangerous disease in childhood with risk of encephalitis and death
Diphtheria carries the risk for severe breathing problems
B Mumps carry the risk for severe breathing problems
Morbilli carry a high risk for pregnant women of adverse pregnancy outcomes
Measles is a dangerous disease in childhood with risk of encephalitis and death
Diphtheria carry the risk for male infertility and hearing impairment
C Mumps carry the risk for severe breathing problems
Morbilli is a dangerous disease in childhood with risk of encephalitis and death
Diphtheria carries a high risk for pregnant women of adverse pregnancy outcomes
Measles carries a risk for male infertility and hearing impairment
D Mumps is a dangerous disease in childhood with risk of encephalitis and death
Morbilli carries the risk for male infertility and hearing impairment
Diphtheria carries the risk for severe breathing problems
Measles carries a high risk for pregnant women of adverse pregnancy outcomes
A
8
MRI examination shows a closed midline deficiency, including the lipoma, and open spinal arch of the
L5 vertebra and a thickened filum terminale. The child is at risk for developing progressive neurological
deficits, affecting lower limbs- and bladder-function.
At which age are such symptoms most likely to occur?
An otherwhise healthy newborn child has a midline lumbosacral subcutaneous lipoma (see picture in exam document canvas)
A In late adult age, when ageing causes degenerative disease.
B At around one-year age, when the child starts to walk.
C At around seven months age, when the child starts to crawl.
D In the time of puberty, when the child is in its growth spurt
Children with a closed midline deficit and a thickened filum terminale are at risk for developing a tethered cord, because the conus is not free to move upwards from the sacrum to the normal position at L1/2 in adult life. Tethering causes stretching of the spinal cord and myelopathy. During
the accelerated length growth at the time of puberty, the conus retracts to its’ adult position at L1/2, but this is counteracted by the tethering, causing stretching of the cord, and the symptoms therefore typically develop at this stage.
At 7- and 12-months age, the conus of the spinal cord is still located distally in the spinal canal, and stretching does not occur. In adulthood, additional degenerative disease can cause
worsening of pre-existing symptoms, but onset at this stage is rare.
Learning outcome: K1
9
A 12-year-old boy with seasonal rhinoconjunctivitis during springtime (birch pollen) is brought to you in general practice due to intense itching in the oral cavity and the throat after ingestion of apples and carrots. Sometimes he even feels that it seems difficult to swallow.
What is the most appropriate advice and information in this situation?
A Inform the patient and his parents that apples and carrots are histamine rich foods that may cause such symptoms, which never will escalate to serious symptoms.
B Inform the patient and parents that the reactions are because of cross-reactivity due to his birch pollen allergy and that such reactions are without potential for serious reactions. He may tolerate
the foods if they are cooked.
C Due to his difficulties with swallowing consider this a serious allergy to apples and carrots and
advise strict avoidance and prescribe an adrenalin auto-injector.
D Inform the patient and parents that the reactions are because of cross-reactivity due to his birch
pollen allergy. Due to possible serious reactions you refer the patient to an allergy clinic to
perform controlled oral challenges with apples and carrots and advise strict avoidance in the
meantime.
B
Correct is that you inform the patient that the reactions are because of cross-reactivity due to his
birch pollen allergy and that such reactions are mild without potential for serious reactions. He
may tolerate the foods if they are cooked.
There are no specific allergies towards apples and carrots, only cross-reactivities (mainly birch).
These allergens are unstable and destroyed by cooking/heating. There is no need for further
testing and no need for adrenaline.
Learning outcome: K4
10
A 7-year-old boy with a history of anaphylaxis in relation to ingestion of cow’s milk at one year of age is
referred to you at the paediatric outpatient clinic. The parents want to know if he has outgrown his allergy to cow’s milk. He has not been exposed to cow’s milk and the specific IgE-value against cow’s
milk has decreased from 62 kU/L to 3.5 kU/L. He has not experienced allergic reactions since the episode at one year of age.
How is it best to proceed to find out if he has outgrown his allergy to cow’s milk?
A No need for further testing. The decrease in IgE to cow’s milk is diagnostic for tolerance. They can introduce small amounts of cow’s milk at home.
B No need for further testing. Most children with cow’s milk allergy become tolerant to cow’s milk by 2-3 years of age. They can introduce small amounts of cow’s milk at home.
C Perform an oral provocation test with cow’s milk. This cannot be done at home since he had experienced anaphylaxis and since he has not been exposed to cow’s milk later.
D Further testing with introduction and elimination of cow’s milk with intervals of 3 weeks.
C
A provocation is recommended, despite falling sIgE levels, and this should not be done at home
since he had experienced anaphylaxis and since he has not been exposed to cow’s milk later.
Learning outcome: K4
11
The parents bring this previously healthy 6-month-old boy to you at your general practitioner office.
He has been coughing for 3-4 days. From this morning his cough and general condition has worsened.
Clinical examination: Respiratory rate 65/min (normal <45/min). Pulse 180/min (normal < 160/min).
SpO2 94%. Capillary re-fill time 2 sec. Temperature 39.5 OC.
Respiration: Sub- and intercostal retractions. Grunting. On auscultation there are reduced respiratory
sounds on lower left side.
CRP 150
What is the most likely diagnosis?
A Asthma exacerbation
B Acute bronchiolitis
C Bacterial pneumonia
D Foreign body aspiration
C
Bacterial pneumonia is most likely. High fever, reduced respiratory sounds lower left lung, grunting and high CRP make you suspect bacterial pneumonia.
In bronchiolitis you would expect to find wheezing and prolonged expiration, and not unilateral reduced breathing sounds. Usually also lower CRP.
No previous history of asthma.
Foreign body aspiration does not typically cause a high fever.
12
A 16-year-old boy is admitted to the paediatric emergency ward where you work as a junior doctor.
He complains about dry cough for around 3 weeks. He tells you that his general condition has
deteriorated, and he has developed breathing problems, first on exertion but now also at rest. He has
also lost 4 kg in weight, has reduced appetite, sweats at night (but did not have fever) and has noticed
enlarged lumps on the neck. On examination, you palpate 3 cm large, firm, untender lymph nodes on
both side of the neck and notice jugular vein distention. His respiratory rate is 26/min (Ref < 20), pulse
105/min, SpO2 95%, temperature 36.6OC. He has normal CRP and normal hematological blood
samples. You take an X-ray of his chest (see picture in canvas):
What is the most likely diagnosis?
A Congestive heart failure with pleural effusion
B Superior vena cava syndrome due to lymphoma
C Pulmonary tuberculosis
D Atypical pneumonia due to a mycoplasma infection
B
Most likely superior vena cava syndrome due to lymphoma. Large mediastinal tumor, enlarged
cervical lymph nodes and B-symptoms. Dyspnea and jugular vein distention indicate a superior
vena cava syndrome.
Normal CRP, no lung parenchyma pathology, no signs of infection; not very suspect for
tuberculois or atypical pneumonia.
Not enlarged heart and young age - no suspected cardiac failure.
Learning outcome: K4
13
A 6-month-old girl comes with her father to the community health care center for a routine check-up.
On examination you find normal findings except that the right leg is approximately 1.5 cm shorter than
the left leg.
What is the best way to manage this finding and why?
A Reassure the father that a minor leg length discrepancy is common and is usually a normal finding
B Order an X-ray of the pelvis/hips to exclude hip dislocation on the right side
C Order an X-ray of the lower extremities to exclude a “green-stick” fracture
D Refer to physiotherapist to correct muscle tone and asymmetry in lower extremities
B
Hip dysplasia/dislocation is the most important underlying condition that can cause leg length
discrepancy and must be rapidly ruled out.
Learning outcome: K1
14
You are a general practitioner. A 3-year-old girl is brought to you by her mom because she has fever
and severe throat pain. She has refused to eat and has increasing difficulties drinking even water.
On examination you find the following clinical picture (white, circular spots on tounge and in throat).
What is the most likely cause of this clinical picture?
A Measles with oral Koplic spots
B Hand, foot and mouth disease
C Herpes simplex virus, primary infection
D Human herpes virus 6 or 7
C
Herpes simplex virus, primary infection may cause a severe stomatitis, as described.
15
As a general practitioner you examine a 6-month-old son, who over the past months has developed a rather large, red lesion on his skull. The lesion first became visible a few weeks after birth like a small
red nodule, but has grown steadily ever since. The child otherwise appears perfectly healthy.
What is the best and most reasonable management of this child?
A Refer the patient to a plastic surgeon to have the lesion removed surgically
B Do nothing for the moment, reassure the parents that this lesion will stop growing and slowly involute
C Have the child examined by computer tomography (CT scan) to rule out a malignant disease
D Tie a string around the lump so that it is strangulated and eventually drops off
B
Infantile vascular haemangiomas usually enlarge during the first months of a child’s life but will then gradually decrease in size and extent during the coming years. Normally one should do nothing and wait for the end result until possible definite surgical correction is performed. Bleeding
haemangiomas might have to be removed earlier. If the location is difficult or if very large, treatment with beta blockers is the best option.
Learning outcome: K1
16
Syndactyly is the most frequent congenital malformation of the upper extremity, whereby fingers fail to separate in utero. In a complex syndactyly the digital bones are also fused (see illustration).
What is the most important reason for surgery of a complex syndactyly?
A The fused fingers might be further deformed as the hand develops
B The deformity might spread to other fingers
C The deformity carries a risk of malignant development
D The child will be bullied by others at school
A
As the hand develops/grows a complex syndactyly will result in further bending of the fingers and
worsened hand function. The function of the rest of the hand might be affected by a severe
distortion from syndactyly.
17
You are a general practitioner, and many children are seen in your practice. Your next patient today is
a 6-year old boy coming with his mother because of bed wetting at night.
What is most likely the best communicative approach for this consultation?
A In order to create a child friendly and good atmosphere, prioritise to let the boy take full control of
the structure of the clinical consultation.
B Focus predominantly on the boy – and not the mother – and try to get most information about the
medical history directly from the boy.
C Talk mainly to the boy because at this age children are capable to distinguish between real
experiences and imagination. The general practitioner can trust what he is telling you.
D Start by talking to the boy and giving him room to settle in order to create a good atmosphere in
the consultation. Then get the medical history mainly from the mother.
D
Giving the child time and room to settle is important and increases the likeliness of a successful
clinical examination later. Medical history at this age will primarily be from the mother. At this age
childen have a lively fantasy and are often not able to to distinguish between real experiences
and imagination. The ability to distinguish between real experiences and imagination develops
later (8-12 years age)
Learning outcome: K4
18
A young woman from Eritrea comes to the labour ward with contractions. She has lived in Norway for 1
year. In the health card for pregnant women, it appears that she is giving birth for the first time, and
that the hepatitis B serology indicates that she is HBsAg and HBeAg positive.
What preventive guidelines concerning Hepatitis B apply to her newborn child?
A No specific guidelines apply in this situation. Hepatitis B vaccine is not included in the Norwegian
child vaccination program
B Give hepatitis B immune globulin (HBIG) and vaccination at birth. Then give vaccine after 1, 3, 5
and 12 months
C Give an accelerated vaccination program due to increased risk of infection: At birth, after 4 weeks
and 3 months
D Follow the usual vaccination program with vaccinations that are given after 3, 5 and 12 months
B
The woman is a chronic carrier and since she is both HBsAg and HBeAg positive there is a high
risk of transmission if no preventative measures. The child must be protected from infection
during/after birth by giving hepatitis B immune globulin (HBIG) and vaccination at birth, and then
give vaccine after 1, 3, 5 and 12 months.
Hepatitis B has been in the in the Norwegian child vaccination program since 2017.
Learning outcome: K3
19
A 6-year-old boy is referred to the pediatric outpatient clinic. His weight has dropped from the 50th percentile to the 2.5th percentile between 4 to 6 years of age. Weight in relation to height is on the
2.5th percentile. His general condition is acceptable. However, the mother thinks he looks pale and tells you that he often has loose stools. The primary laboratory investigation showed:
Hb 9.8 g/dL (ref.: 11.5-14.5 g/dL)
Ferritin 3 μmol/L (ref.: 15-100 μmol/L)
Calprotectin test in stool is negative (low value)
Which test is most likely to reveal the cause of his anemia/his condition?
A Specific IgE against cow’s milk protein
B Anti-tissue transglutaminase
C A Hemofec to detect blood in faeces
D Skin test with food allergens
B
Celiac disease often causes relatively few symptoms, but affects growth and often results in iron deficiency anaemia due to malabsorption.
Occult blood will most often not reveal the cause of iron deficiency anemia in children, where the cause is most often low intake or malabsorption
Food allergy, including Cow’s milk protein allergy, will most often cause more pronounced skin
and gastrointestinal symptoms and rarely growth abnormalities
Learning outcome: K4
20
You are a general practitioner. A mother brings her 18-month old son who has fever, cough and a runny nose. He is in good general condition and previously healthy with normal development.
On examination you hear a mid-systolic cardiac murmur grade II that has not been noted at previous examinations. He has normal peripheral circulation, and the liver is not enlarged. He has a normal
oxygen saturation. Which approach to the patient’s cardiac murmur is most appropriate?
A All cardiac murmurs in children should immediately be examined by echocardiography.
B You reassure the mother that the murmur you heard is innocent and that it does not need to be followed up.
C You assume that the murmur is physiological and book a new appointment in order to control it when the patient no longer has fever.
D The patient should be referred to a pediatric cardiologist since the murmur most likely is caused by a previously not diagnosed congenital heart defect.
C
Most appropriate is that you assume that the murmur is physiological due to the influence of the
fever on the circulation, but you book a new appointment in order to control it when the patient no
longer has fever. Children with murmur during fever do not need immediate referral to pediatric
cardiologist.
Learning outcome: K4
21
You are a general practitioner. A mother comes to you with her 4-year old daugther
She has for 3-4 months had small amounts of soft stool in her underpants (soiling) almost every day.
The girl is otherwise healthy, but often complains about abdominal pain. The parents are frustrated and
concerned.
What is the most likely cause for this problem?
A A progressive neurological deficit
B Celiac disease
C Constipation
D Attention deficit hyperactivity disorder
C
Functional constipation is very common and by far the most common cause of fecal incontinence
in otherwise healthy children.
Learning outcome: K4
22
You work as a general practitioner. A mother brings her 8-year-old son. He has had three attacks of
severe headache over the last 15 months, starting first time when he was seven years old. He vomits during these attacks and wants to sleep in a dark room. After 2-3 hours of sleep, he usually recovers
well. His mother and grandmother both have migraine. What would be the best advice in this situation?
A If severe pain during migraine attacks, morphine tablets are first choice in children
B Always prescribe triptan tablets as first-line acute therapy of migraine attacks in this age group
C Recommend ibuprofen, paracetamol and maybe an antiemetic if there are new migraine attacks
D Start prophylactic therapy with a beta-blocker due to the frequent migraine attacks
C
Not very frequent attacks, no indication for prophylactic therapy.
Ibuprofen and paracetamol first choice, sometimes combined with an antiemetic
Triptan nasal spray indicated from 12 years of age, but used as second choice if no effect of
NSAIDs, paracetamol down to 10 years of age (or even younger)
Opioids not used for migraine attacks
Learning outcome: K5
23
The Hippocratic Oath is one of the most widely known Greek medical texts.
What are the four major principles of medical ethics – partly based on The Hippocratic Oath?
A Beneficience, non-maleficence, fidelity and accountability
B Beneficence, non-maleficence, justice and respect for autonomy
C Respect, transparancy, sustainability and justice.
D Solidarity, dignity, justice and autonomy
B
Correct is: Beneficence, non-maleficence, justice and respect for autonomy
Learning outcome: K4
24
A woman gives birth rather quickly in the ambulance on her way to hospital. You are the doctor on call in the ambulance.
The child comes out blueish-purple with pale limbs, and is rather floppy. Palpating the cord you can feel a pulse of 120 beats/minute, and the baby gasps a little. You start drying and stimulating the baby.
Very quickly, within a minute, the baby is crying loud, spitting when you insert a suction catether, moving his arms and legs vigorously and is starting to achieve a bright, pink colour on his face and trunk. Arms and legs are still purple.
What Apgar score at 1 minute will you give this baby?
A 3
B 5
C 7
D 9
Respiration: 2 (crying loud)
Circulation: 2 (heartbeat > 100/min)
Tone: 2 (moving arms and legs2
Reflexes: 2 (reaction to suctioning)
Skin colour: 1 (pink central, cyanotic extremities)
Total Apgar-1 min score 9
Learning outcome: K3
25
Different antibiotic classes have different modes of action (difference in pharmacodynamics).
Which is the correct statement regarding these antbiotic classes?
A Macrolides target the bacterial cell membrane
B Sulfonamides inhibit synthesis of folate
C Beta lactams inhibit bacterial protein synthesis
D Glycopetides inhibit beta lactamases
B
Learning outcome: K8
26
You work as a junior doctor in a large paediatric department. A mother who has not been to antenatal
ultrasound screening has just delivered a baby. You are called to the labour ward to see this baby
which is born with a congenital malformation, see picture (Pic of intestines outside abdomen not covered by peritoneum). What is the diagnosis/name of this
condition?
A Omphalocele
B Gastroschisis
C Bladder extrophy
D Pyloric stenosis
B
Correct is gastroschisis
Learning outcome: K1
27
You work as a junior doctor in a neonatal unit. Today you are in charge of a little girl born prematurely
by caserean delivery at 29 weeks gestation. You have started treatment with non-invasive respiratory
support, but the baby is having increasing breathing difficulties and she needs 50% oxygen to maintain
SpO2 > 90%.
What is the most likely reason for her breathing difficulty?
A Respiratory distress syndrome because of lack of surfactant
B Persistent pulmonary hypertension and constricted pulmonary vasculature
C Respiratory distress syndrome because of too much surfactant
D Wet lungs with too much amniotic fluid in the lungs
A
She was born 11 weeks prematurely. The most likely reason in this situation is Respiratory
distress syndrome because of lack of surfactant
Learning outcome: K3
28
You work as a junior doctor in a neonatal unit and collaborate closely with the midwives. It is
recommended to delay the clamping of the cord after a baby is born.
What is the physiology behind the beneficial effects of delayed cord clamping?
A The baby may provide fetal blood via the umbilical artery to the placenta and thereby preventing postnatal lung fluid overload which improve breathing
B The baby will receive a “transfusion” of extra blood from the placenta and the umbilical vessels, but mainly before the child has started breathing.
C The baby will receive a “transfusion” of extra blood from the placenta and the umbilical vessels, and even more if waiting to after the child has started breathing
D The baby will not receive a “transfusion” of extra blood, but the contact with the mother is important for temperature control and bonding
C
Most correct is that the baby will receive a “transfusion” of extra blood from the placenta and the
umbilical vessels, and even more if waiting until the child has started breathing. There is usually
not more flow going from the baby to placenta
Learning outcome: K3
29
You are a junior doctor in the pediatric department. Today you see a 5-year old girl who recently was
diagnosed with juvenile idiopathic arthritis (JIA). The parents have heard that their daughter is at risk of
developing extra-articular manifestations, and want advice on this.
What is the most common extra-articular feature of JIA?
A Dermatitis
B Sinusitis
C Nephritis
D Uveitis
D
Uveitis is found in 10-25% of children with JIA, while the other are rare or not relevant.
30
You are a general practitioner. Today you see a 15-year old girl who is a refugee from Congo arriving in Norway around 5 months ago. She came to you 2 months ago and complained about a troublesome cough. You gave her a course of antibiotics due to a suspected lower respiratory tract infection. At that
time her sedimentation rate (SR) was 65 mm (ref. <10 mm). Her cough has not become better and now she comes back and tells you, via an interpreter, that she has lost around 5 kg of weight over last
2 months. She has also been sweating at night and the coughing is even worse.
Which diagnostic procedure should you prioritize in this situation?
A C-reactive protein (CRP) test in serum
B Nasopharyngeal swab for influenzae and respiratory viruses
C Serology for Mycoplasma pneumonia and Chlamydophila pneumoniae
D Interferon-gamma-release-assay (IGRA) blood test
D
The clinical history (land of origin, chronic cough, elevated SR, sweating at night and weight loss)
makes TB highly suspicious. IGRA test would be positive if it is TB (high sensitivity of the IGRA
test in this age group). CRP is unspecific. M. or C. pneumoniae/respiratory viruses rarely have
many months of symptoms.
Learning outcome: K4
31
Your are a junior doctor in the pediatric outpatient clinic. A 16-month-old boy is referred because he
has been coughing more or less every day over the last 3-4 months. The parents can often hear
wheezing sounds from the chest. It started with a respiratory tract infection (RTI) shortly after starting
in kindergarten. Later he has had four episodes with acute exacerbations related to viral RTIs, but
also milder symptoms in between infections. During the night, he often coughs until he is vomiting
mucus.
There are family members with atopic disease on both sides of his family.
What would be the most appropriate first therapy for this child?
A Inhaled corticosteroid given as inhalation aerosol on a chamber with a face mask twice daily and
short acting beta-2-agonist given the same way when needed.
B Short acting beta-2-agonist given as inhalation aerosol on a chamber with a face mask when
needed or 4 times daily every day.
C Corticosteroid inhalations given via a nebuliser twice daily and short acting beta-2-agonist
inhalations given the same way as needed.
D Combined inhaled corticosteroid and long acting beta-2 agonist given as powder inhalator and
leukotrien receptor antagonist mixture. Short acting beta-2 agonist given as powder inhalations
when needed.
A
Best is to start with inhaled corticosteroid (ICS) given as inhalation aerosol on a chamber with a
face mask twice daily and short acting beta-2- agonist given the same way as needed. The child
will most likely benefit most from ICS, and he has asthma.
He should have prophylactic therapy (ICS), not only short acting beta-2 agonist.
Nebuliser therapy twice daily is not the first choice as it is cumbersome.
He is too young for powder inhalator
Learning outcome: K4 and K8
32
A 7-year-old boy is admitted to the paediatric department with a new-onset diabetes. You are the junior
doctor on call. On examination he is breathing fast and deep and looks dehydrated.
He responds slowly to your questions. SpO2 is 98% (> 94%). Blood pressure is normal.
Laboratory parameters including a blood gas show:
Plasma glucose 26 mmol/L (Ref < 7 mmol)
pH 7.05 (Ref 7.35-7.45)
pCO2 2.7 kPa (Ref 4.5-6.5)
Bicarbonate 5 mmol/L (Ref 22-26)
What are the main principles and correct order of medical treatment for this child?
A
* Intravenous fluid resuscitation
* Intravenous insulin infusion to reverse ketosis and reduce plasma glucose
* Intravenous potassium to restore losses
B
* Intravenous insulin infusion to reverse ketosis and reduce plasma glucose
* Intravenous sodium to restore losses
* Intravenous fluid resuscitation
C
* Subcutaneous insulin to slowly reverse ketosis and reduce plasma glucose
* Intravenous fluid resuscitation
* Intravenous sodium to restore losses
D
* Intravenous bicarbonate to correct acidosis
* Intravenous insulin infusion to reverse ketosis and reduce plasma glucose
* Intravenous potassium to restore losses
This child has a severe diabetic ketoacidosis.
Main principles for therapy and order of these therapies are: IV fluid, IV insulin and potassium
correction
Learning outcome: K4