Ddx Flashcards

Question

Autosomal dominant auto inflammatory syndromes

Answer 1

TRAPS: TNF Rc ass periodic Synd CAPS: cryopyrin ass periodic Synd > muckle wells > familial cold auto inflam Synd > NOMID: neonatal onset multi system inflam disease PAPA: Pyogenic arthritis, PG & acne PGA: paediatric granulomatous arthritis

Answer 2

``` Familial Mediterranean Synd>> (ass w: recurrent fever, cellulitis & abdo px) Hyper IgD Synd Mevalonic aciduria DIRA: deficiency of il1 rc antagonist Marjeed Synd Early onset IBDz ```

Answer 3

``` Cellulitis Erysipelas Atypical mycobacterium Deep fungi infn Sarcoidosis Lymphoma Drug Cold Trauma Auto inflammatory Synd: familial Mediterranean fever, TRAPS Paniculitis EN ```

Answer 4

``` BACTERIAL Norcardia* Cat scratch Tularemia Glanders Staph aureus ``` ``` MYCOBACTERIA TB Atypical mycobacteria - marinum - chelonei - fortuitum - kansasii ``` ``` DEEP FUNGAL Sporotrichosis* Blastomycosis Chromoblastomycisis Histoplasmosis Coccidioidomycosis ``` ``` PROTOZOA American Leishmaniasis (old world leishmaniasis does not cause sporotrichoid spread) ``` ALGAE Protothecosis * these can ulcerate!! Important: syphilis is NOT sporotrichoid spread

Answer 5

``` Idiopathic: Polymorphous light eruption Actinic prurigo Solar urticaria Hydroa vacciniforme Chronic actinic dermatitis ``` ``` Metabolic/ nutritional: Pellagra (def B3/ niacin) Carcinoid (def B3) Hartnup (def B3) Kwashiorkor (def B3) Isoniazid (depletes B3) Porphyria: PCT, VP ``` CT Dz: Lupus Dermatomyositis External agents: Psoralens: lime, bergamot, orange, fig, parsley, celery Dyes: methylene blue, rose Bengal Coal tars Photo drug: photo toxic & photo allergic Drugs: tetracyclines, thiazides, naprosyn, griseofulvin, isotretinoin Photo contact Phytophoto Fragrance ``` Photo aggravated dermstoses: Rosacea AD Pemphigus foliaceous Dariers REM Jessners LP Actinicus DSAP ``` ``` Congenital XP Blooms Cockaynes Rothmund Thompson PIBIDS Chronic granulomatous disease ```

Answer 6

``` EM Fixed drug Urticaria Kawasaki Puppp Pemphigus gestationis Vasculitis Rowell syndrome- EM like lesions of lupus PMLE ```

Answer 7

Common causes: EN Erythema induratum (inc TB) Vasculitis: nodular, PAN ``` Less commonly: Infn: deep fungi, TB, atyp MB, bact, toxocariasis Granulomatous: sarcoidosis, NLD, GA Neoplastic: lymphoma, tumours Immune: lupus, scleroderma, eosinophilic fasciitis Drug: PO steroids Physical: artefactual, cold, trauma Metabolic: a1AT def, pancreatic ```

Answer 8

``` Erythema gyratum repens Erythema annulare centrifcum Tinea SCLE , neonatal LE GA Sarcoid Urticaria Fixed drug eruption Giant plaque form morohoea Psoriasis/ eczema/ Seb derm Erythema chronicus migrans - Lyme dz Necrolytic migratory erythema - glucagonoma DA Erythema marginatum- rheumatic fever DFSP CTCL Leprosy Deep fungal Tb Stills ```

Answer 9

Cells: Neutrophils- EED, sweets, PG, granuloma facials, autoinflammatory syndromes (PAPA, PASH, DITRA, CANDLE) Lymphocytes: PMLE, jessners, leukaemia cutis, lymphoma, leukaemia Eosinophils: wells, hyper eosinophilic syndrome, insect bite Mast cells Histocytes Xanthomas Substances: Mucinoses Hyaline: amyloid, systemic hyalinosis, lipoid proteinosis, colloid Glycolipid: farbers, fabrys, Niemann pick, stiff skin Calcium Urate Cholesterol

Answer 10

``` Bacteria: staph & strep, (ecthyma), pseudomonas, diphtheria Mycobacteria Fungi Viral: HSV, CMV, cowpox, orf, millers nodule, mollucsa Chlamydia Rickettsia Protozoa Algae: protothecosis ```

Answer 11

``` Anthrax Tularemia Cat scratch Plague Spirillum minor rat bite fever Pasturella multocida (cat and dogs) ```

Answer 12

Glanders Meliodosis Capnocytophagia canimorsus- dog bite or human bites! Staph/ strep Typhus: scrub and tick Trypanosomiasis: African and American (chagus dz)