DDW board review Flashcards
1
Q
Who to screen for high risk panc ca?
A
- all pts w/ Peutz-Jeghers (carry LKB1/STK11 gene mutation)
- all carriers of germline CDKN2A (FAMMM - familial atypical multiple mole melanoma/dysplastic nevus syndrome)
- carriers of the following AND at least one affected 1st-degree relative: BRCA 1&2, PALB2, ATM, MLH1, MSH2, MSH6
- pts w/ at least one first degree relative w/ panc ca (who themselves have a relative w/ panc ca)
2
Q
Peutz-Jegher mutation?
A
STK11/LKB1
3
Q
Hereditary panc mutation?
A
PRSS1
4
Q
familial atypical multiple mole/dysplastic nevi syndrome gene
A
CDKN2A
5
Q
Lynch syndrome genes
A
MLH1, MSH2, MSH6
6
Q
Li Fraumeni syndrome gene
A
TP53
7
Q
Hereditary breast and ovarian cancer genes
A
BRCA 1, BRCA 2, PALB2
8
Q
A
