DDR

Question 1

DDR DEF

Answer 1

Multiple biochemical signalling pathways that together coordinate the
proper cellular responses to structural perturbations in the genetic material (e.g. DNA damage)

Question 2

WHY TUMOUR SUPPRESSIVE

Answer 2

1.Eliminates Damaged Cells:
If DNA damage is too severe, DDR can induce apoptosis (programmed cell death) or cellular senescence, removing potentially cancerous cells from the proliferative pool.
2. Prevents Mutation Accumulation:
By repairing DNA lesions, DDR prevents mutations that can activate oncogenes or deactivate tumour suppressor genes.
3. Enforces Cell Cycle Checkpoints:
DDR halts the cell cycle at G1/S, intra-S, or G2/M phases, preventing the replication or segregation of damaged DNA