DDI's

Question 0

PI’s–>ICS inhaler

Answer 0

Adrenal insufficiency (fluticasone and budesonide)

Use beclomethasone or mometasone

Question 1

PI’s –>statins

Answer 1

Simva/lova increase myopathy

Use low dose prava/atorva. Rosuva preferred

Question 2

NNRTI’s —> PPI’s

Answer 2

Inhibits rilpivirine absorption

Use H2RA separate by 12 hrs

Question 3

PI’s —> sildenafil

Answer 3

Hypotension visual disturbances, priapism

C/I for pulmonary arterial HTN
Low dose for ED

Question 4

INSTI’s —> metformin

Answer 4

Increases metformin

Monitor SCr maybe d/c metformin

Question 10

INSTI’s—> rifampin

Answer 10

Decrease INSTI levels

Use rifabutin

Question 11

Elvitegravir/cobicistat—> warfarin

Answer 11

High or low warfarin levels

Monitor INR

Question 12

Dolutegravir—> efavirenz, fosampranvir, rifampin

Answer 12

Low dolutegravir levels

Increase to 50mg bid

Question 13

Maraviroc—>ritonavir

Answer 13

Increased maraviroc

Lower to 150mg bid

Question 14

PI’s—> PPI’s

Answer 14

C/I

Use H2RA separated by 12hrs