Day 3 PM

Question 1

What is the brand name for Metoclopramode?

Answer 1

Reglan

Question 2

Which receptor(s) does Reglan antagonize?

Answer 2

Dopamine receptors and 5-HT3 receptors

Question 3

What is the brand name for Ondansetron HCl?

Answer 3

Zofran

Question 4

What drug class is considered the gol standard treatment for chemotherapy, and radiation induced nausea and vomitting?

Answer 4

5-HT3 (serotonin) receptors

Question 5

What use is Dolasetron indicated for by the FDA?

Answer 5

PONV - post operative nausea and vomitting

Question 6

What activates NK1 receptors?

Answer 6

Substance P

Question 7

Name the drug that is used to antagonize NK1 receptors in the CNS

Answer 7

Aprepitant (Emend)

Question 8

What type of receptor is the 5-HT3 subtype?

Answer 8

Na/K ligand gated ion channel

Question 9

Give the location of 5-HT3 receptors in the ENS

Answer 9

Afferent parasympathetic nerves in GI tract - vagal and splanchic nerve

Question 10

Give the location of 5-HT3 receptor subtype in the CNS

Answer 10

NTS - nucleus of the solitary tract

CTZ - chemoreceptor trigger zone

Question 11

What section of the pharmacophore of 5-HT3 antagonist is responsible for increasing its lipophillicity?

Answer 11

The tertiary Nitrogen and how complexed it is