Day 1 Flashcards
1
Q
- Caris conduct Whole ______ Sequencing that tests DNA
A
Exome
2
Q
- Caris conducts Whole _______Sequencing that tests RNA
A
Transcriptome
3
Q
- Whole Exome Sequencing can identify the following
A
Mutations, Indels, and Copy Number Variants
4
Q
- Whole transcriptome sequencing can identify the follow
A
Fusions and variant transcriptions
5
Q
- Protein alterations/errors that can occur at
A
Mutations and/or fusions, loss of expression, and over expression
6
Q
- Next-generation sequencing is the catch-all term used to describe several, different, modern sequencing technologies of DNA and RNA
A
True
7
Q
- Caris, WES, sequences the entire genome
A
False (sequences all exons on the DNA-1% of total genome)
8
Q
- DNA sequencing looks at errors in the gene. From this, it is inferred how the protein would be impacted. Whereas IHC testing, we are directly evaluating the protein to see if it is
A
Abnormal, over expressed, and under expressed
9
Q
- The _______theory is the 2 step process of transcription and translation (of information flow from DNA to Proteins)
A
Central Dogma
10
Q
- Caris micro dissects proactively?
A
True
11
Q
- Tissue requirements can also be found on the Caris
A
requisition
12
Q
A________is used to make extremely thin slices/sections of tissue
A
Microtome
13
Q
- A majority of specimens received by Caris are in the form of? Core needle biopsy/unstained slides
A
Parafin embedded block (FFPE)
14
Q
- For Formalin-Fixed Paraffin Embedded blocks, Caris requires at least ______tumor nuclei
A
20%
15
Q
- QNS can mean both _______ and _______:
A
Quantity and Quality insufficient
