Daptomycin

Question 1

A cyclic lipopeptide antibiotic that acts on the cell ________ (not cell wall) causing rapid depolarization and disruption of membrane function

Answer 1

membrane

Question 2

What is Daptomycin used to treat?

Answer 2

Used only for G+ including MRSA and VRE

Question 3

Example of gram + bacilli daptomycin treats

Answer 3

corynebacterium Jeikeium

Question 4

Example of gram + cocci daptomycin treats

Answer 4

enterococcus faecalis
enterococcus faecium
Staph aureus (MRSA and MSSA)
streptococcus pneumonias (penicillin resistant)
streptococcus pyogenes

Question 5

What is daptomycin inactivated by?

Answer 5

pulmonary surfactant

Question 6

which disease process would you avoid using daptomycin in?

Answer 6

pneumonia (deactivated. by pulmonary surfactant)

Question 7

daptomycin can be used in Treatment of bloodstream infection caused by Staphylococcus aureus (methicillin-susceptible and methicillin-resistant isolates) in adults, including those with ___-sided infective endocarditis

Answer 7

right

Question 8

Daptomycin can cause Myopathy/rhabdomyolysis, how to monitor for this?

Answer 8

Discontinue in patients with signs and symptoms of myopathy in conjunction with an increase in CPK (>5 times ULN or 1,000 units/L) or in asymptomatic patients with a CPK ≥10 times ULN or >2,000 units/L.

Question 9

Possible cardiovascular side effects of daptomycin

Answer 9

Chest pain (adults: 7%), edema (adults: 7%), hypertension (adults: 6%), hypotension (adults: 2%)

Question 10

Possible CNS side effects of daptomycin

Answer 10

Insomnia (adults: 9%), headache (3% to 5%), dizziness (adults: 2%)

Question 11

Possible dermatologic side effects of daptomycin

Answer 11

Pruritus (3% to 6%), diaphoresis (adults: 5%), skin rash (adults: 4%)

Question 12

Possible GI side effects of daptomycin

Answer 12

Diarrhea (5% to 7%), abdominal pain (adults: 6%; children and adolescents: 2%), vomiting (children and adolescents: 3% to 11%; adults: <1%)

Question 13

Possible GU side effects of daptomycin

Answer 13

Urinary tract infection (adults: 2%)

Question 14

Possible hepatic side effects of daptomycin

Answer 14

Abnormal hepatic function tests (adults: 3%), increased serum alkaline phosphatase (adults: 2%)

Question 15

Possible respiratory side effects of daptomycin

Answer 15

Respiratory: Pharyngolaryngeal pain (adults: 8%), dyspnea (adults: 2%)

Question 16

how often should you measure CPK concentration while on daptomycin?

Answer 16

weekly

if on statin may do more frequent than weekly.

Question 17

daptomycin Use may result in eosinophilic pneumonia; generally develops 2 to 4 weeks after therapy initiation. Monitor for signs and symptoms of eosinophilic pneumonia, including ________________.

Answer 17

new onset or worsening fever, dyspnea, difficulty breathing, new infiltrates on chest imaging studies, and/or >25% eosinophils present in bronchoalveolar lavage.

Question 18

Discontinue Daptomycin use immediately with signs/symptoms of eosinophilic pneumonia and initiate appropriate treatment (ie, ________).

Answer 18

corticosteroids