DA

Question 1

Antiplatelets

Answer 1

Prevent blood from clotting, decrease platelet aggregation and inhibit thrombus formation in arterial circulation

Question 2

Types of antiplatelet drugs

Answer 2

Aspirin, Clopidogrel, Dipyridamole

Question 3

Drugs used to prevent further CV disease

Answer 3

Antiplatelets, lipid lowering drugs, anti-arrhymias, anticoagulants, diuretics, ace-inhibitors

Question 4

Drugs used to reduce symptoms of CV disease

Answer 4

Diuretics, anti-arrhymias, nitrates, calcium channel blockers, ACE-inhibitors

Question 5

Aspirin MOA

Answer 5

Inhibits platelet aggregation, alters balance of throboxane A2 and prostacyclin

Question 6

Clopidogrel MOA

Answer 6

Inhibits ADP induced platelet aggregation

Question 7

Dipyridamole MOA

Answer 7

Inhibits platelet phosphodiesterase

Question 8

Aspirin, Clopidogrel and Dipyridamole in combination

Answer 8

Significantly reduce chance of heart attack and stroke

Question 9

Effects of antiplatelets on dentistry

Answer 9

Prolong bleeding time following dental extraction, drug combinations increase the risk

Question 10

Which drug reduces the risk of an MI

Answer 10

Aspirin

Question 11

Anticoagulants

Answer 11

Used to prevent blood clots, reduce chance of developing serious conditions like strokes/heart attacks

Question 12

Types of anticoagulants

Answer 12

Warfarin, rivaroxaban, dabigatran

Question 13

Warfarin MOA

Answer 13

Inhibits function of enzyme for Vitamine K to produce clotting factors. Makes blood flow easier through the veins, blood less likely to clot

Question 14

For what conditions is Warfarin prescribed

Answer 14

further blood clots, deep vein thrombsis DVT, pulmonary embolism, heart attacks, strokes

Question 15

Dental implications of using Warfarin

Answer 15

Bleeding easier than normal. Exctractions ect. may not clot and have prolonged bleeding. INR test.

Question 16

Cannot take Warfarin if px has these conditions;

Answer 16

Endocarditis, hypertension

Question 17

Oral anticoagulants

Answer 17

Inhibits clotting cascade, doesn’t affect platelets. Reduces amount of fibrin formed and clot ability. No increased bleeding problem but increase in post-bleeding hours later