D. Major Metabolic Pathways - Synthesis and Degredation of Macromolecules(lipid) Flashcards
Lipids Fatty Acid Oxidation
What happens in the second step, where Acyl-CoA is used to be converted into…. What enzyme is involved?
Acyl CoA, the acyl portion is transfered to carnitine, then crosses membrane and back to Acyl-CoA.
Carnitine palmitoyl transferases 1 (cytosol) 11 (matrix)
Lipids - Fatty Acid Oxidation.
What is the first step? What is the enzyme that is responsible?Where are they located?
Fatty Acid Activation - before FAs can be oxidised they need to be primed for the reaction in an ATP dependent acylation reaction for form fatty acyl-CoA
Fatty Acid + CoA + ATP -> acyl-CoA + AMP + PPi
acyl-CoA synthetases (thiokinases), multiple families with chain- length specificites. Located in the endoplasmic reticulum or the outer mitochondrial membrane.
