CYTOTOXIC DRUGS NEW Flashcards
1
Q
Anthracyclines examples
A
Daunorubicin
Doxorubicin
Epirubicin
Idarubicin
2
Q
Anthracyclines: SE
A
- RUBI-red urine
- Cardio toxic
- Dehydration/diarrhoea
3
Q
What is important safety information regarding Doxorubicin
A
- Hand-foot syndrome (painful reddening skin eruptions)
- Treat by cooling hands or feet and avoid using gloves and socks
4
Q
Antineoplastics examples
A
Bleomycin
Mitomycin
5
Q
Antineoplastics SE
A
- Pulmonary fibrosis
- Skin reactions
6
Q
Taxanes examples
A
Cabazitaxel
Docetaxel
Paclitaxel
7
Q
Taxanes SE
A
- Cardiac
- Sepsis risk increases
Paclitaxel = arrythmias
8
Q
Vinca alkaloids examples
A
Vinblastine
Vincristine
Vindesine
9
Q
Vinca Alkaloids SE
A
- CNS toxicity - IV only
- Bronchospasms
10
Q
Signs of CNS toxicity
vinca alkaloids
A
Neuralgia
Jaw pain
Burning sensation
Muscle spasm
11
Q
Anitmetabolites examples
A
Methotrexate
Mercaptopourine
5FU
Capecitabine
12
Q
What is the relationship between 5FU and capecitabine
A
Capebitabine is prodrug of 5FU
13
Q
Antimetabolites SE
A
- Oral mucositis
- Myelosuppression
14
Q
Alkylating drugs examples
A
Cylophosphamide
Ifosphamide
Carmustine
Bendomustine
Melphalan
15
Q
Alkylating agents SE
A
- Damages sperm
- Increased risk of permanent male sterility
- Cystitis
