Cytotoxic Drugs

Question 1

Drug Handling the chemo of cancer should be limited to…. And ….by….. personnel

Answer 1

The chemotherapy of cancer should be limited to specialists in oncology:

• reconstituted by trained personnel
• reconstituted in designated pharmacy areas
• wear protective clothing (gloves, gowns and masks)
• use eye protection
• avoided by pregnant staff (females of child bearing age informed of hazard)
• use local procedures for spillages, safe disposal, including syringes, containers and absorbent material
• monitor staff exposure to cytotoxins

Question 2

Alkylating agents(mide)

Answer 2

cyclophosphamide, ifosfamide, melphalan

Question 3

Extravasion of intravenous drugs can cause what due to leakage….

Answer 3

Severe local tissue necrosis due to leakage of the cytotoxin

Question 4

Oral muscositis is when you develop a …. From using? What is a good piece of advice regarding fluorouracil? What do we mean by treating is less effective? If its caused by methotrexate what can we use?

Answer 4

• sore mouth associated with fluorouracil ,methotrexate and anthracyclines
• advice good oral hygiene and sucking ice chips with fluorouracil
• treating is less effective than preventing - treat with saline mouthwashes
• if caused by methotrexate, use folinic acid(levefolinic acid)

Question 5

Anthracyclines(the -cins)

Answer 5

daunorubicin, doxorubicin,epirubicin,idarubicin

Question 6

Antimetabolites

Answer 6

cytarabine, fluroruracil, methotrexate,mercaptopurine

Question 7

Cytotoxic antibiotics

Answer 7

bleomycin, mitomycin

Question 8

Platinum compounds(end in platin)

Answer 8

carboplatin, cisplatin, oxaliplatin

Question 9

Taxanes(taxel)

Answer 9

cabazitaxel, docetaxel, paclitaxel

Question 10

Vinca alkaloids

Answer 10

vinblastine, vincristine, vindsine