Cytotoxic drug classes Flashcards by Jullianna Paggabao

Q

Anthracyclines (cytotoxic abx)

A

Doxorubicin (bile excretion)

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Q

Vinca alkaloids

A

Vincristine

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Q

Antimetabolite

A

Mercaptopurine
Methotrexate

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Q

Retinoid

A

Tretinoin

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Q

Alkylating drugs

A

Cyclophosphamide

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Q

Platinum

A

Cisplatin
Carboplatin

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Q

Podophyllotoxin derivative

A

Etoposide

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Q

Topoisomerase I inhibitor

A

Topotecan

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Q

Taxane

A

Docetaxel

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Q

Vinca alkaloid: route

A

IV

Never intrathecally = fatal
Adult + adolescent unit: receive doses in 50ml mini infusion bag
Child unit: receive doses by syringe

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Q

Vinca alkaloid: side effect

A

Neurotoxicity
Severe bronchospasm

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Q

Anthracycline cytotoxic abx: side effect

A

Radiomimetic: avoid radiotherapy

Cardiotoxicity + Extravasation injury

Antidote: dexrazoxane
However causes: Hand + foot
syndrome
Cool hands + feet
Avoid socks + gloves for 4-7 days

Red urine

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