Cytotoxic Agents And MOA

Question 1

Cyclophosphamide

Answer 1

Alkylating agent
Cross linking of DNA

Question 2

Bleomycin

Answer 2

Degrades preformed DNA
( cytotoxic antibiotics)

Question 3

Anthracyclines
( doxorubicin)

Answer 3

Stabilizes DNA topoisomerase II
inhibits DNA & RNA synthesis

Cytotoxic antibiotics

Question 4

Methotrexate

Answer 4

Inhibits Dihydrofolate reductase &
Thymidylate synthesis

Question 5

Fluorouracil

Answer 5

Pyrimidine analogue
Inducing cell cycle arrest and apoptosis by blocking thymidylate synthase
Works during S phase

Anti metabolite

Question 6

6 mercaptopurine

Answer 6

Purine analogue activated by HGPRTase
Decreasing luring synthesis

Question 7

Cytarabine

Answer 7

Pyrimidine antagonist
Intereferes with DNA Synthesis at Sphase of cell cycle
Inhibits DNA polymerase

Anti metabolite

Question 8

Vinceistine
Vinblastine

Answer 8

Inhibits formation of microtubules

Question 9

Docetaxel

Answer 9

Prevents microtubule depolymerization and disassembly
Decreasing free tubulin

Question 10

Irinotecan

Answer 10

Inhibitor topoisomerase I which prevents relaxation of supercoiled DNA

Question 11

Cisplatin

Answer 11

Cross linking in DNA

Question 12

Hydroxy urea

Answer 12

Inhibits ribonucleotide reductase
Decreasing DNA synthesis