cytoskeleton

Question 1

what are the three types of filaments in the cytoskeleton?

Answer 1

actin filaments
intermediate filaments
microtubules

Question 2

which is the smallest type of filament?

Answer 2

actin filament

Question 3

where do microtubules grow out of?

Answer 3

the centrosome

Question 4

is the plus end or the negative end of the microtubule closest to the centrosome?

Answer 4

the negative end

Question 5

which end is the fast growing end?

Answer 5

the plus end

Question 6

which filament is made out of alpha- beta tubulin dimers?

Answer 6

microtubules

Question 7

is the beta tubulin postive or negative?

Answer 7

postive- therefore at the plus end

Question 8

what is the tubulin code?

Answer 8

when tubulin is post translationally modified allowing it to be diverse

Question 9

if the microtubulin loses is cap and GDP formed is this fast growing or slow growing?

Answer 9

slow growing

Question 10

what are the 3 function of microtubules?

Answer 10

• cargoing
• mitosis
• cilia

Question 11

what are kinesin and dynesins?

Answer 11

MAPs / motor proteins that use microtubules as tracks for transport

Question 12

does kinesin move to the cell periphery or to the centrosome?

Answer 12

cell periphery

Question 13

what are Tau and MAP2?

Answer 13

they are MAPs that stabilise microtubules

Question 14

what is spastin?

Answer 14

a protein that severs tubulin so can add more units, becomes more dynamic

Question 15

what kind of cilia has a 9+0 formation as oppose to a 9+2 formation?

Answer 15

immotile cilia

Question 16

what protein defect causes lissencephaly?

Answer 16

alpha- tubulin

Question 17

which motor protein defect causes hereditary spastic paraplegia?

Answer 17

kinesin-1