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Second Year Microbiology > Cytokines, TH Pathways and Soluble Factors > Flashcards

Cytokines, TH Pathways and Soluble Factors Flashcards

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Biology 101 flashcards
1
Q

Chemokines

A
  • Adaptive Immune System
  • Attract cells with appropiate receptors (CC or CXC)
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2
Q

TGF-B

A

T reg Pathway

  • Produce TGF-B, IL-10
  • Regulate anti-self responses
  • CD4+, tolerogenic DCs
  • Predominant in GALT

With IL-6

  • TH 17 Pathway
  • Produce IL-6, IL-17
  • Recruit neutrophils
  • Autoimmune damage
  • Barrier integrity
  • Fungi
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3
Q

IL-6

A

Inflammatory

With TGFB

  • TH 17 Pathway
  • Produce IL-6, IL-17
  • Recruit neutrophils
  • Autoimmune damage
  • Barrier integrity
  • Fungi

TFH Pathway

  • Make IL-21
  • Helps B cells

Produced by Th17

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4
Q

IL-12

A

Stimulatory

Th1

  • Make IFNy, TNF
  • Macrophages
  • B cell help (IgG)
  • Inflmmation
  • Attack intra and extracellular bacteria
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5
Q

IL-33

A

Th2 (with IL-4)

  • Produce IL-4, IL-5, IL-13
  • Help B cells (IgE)
  • Parasites
  • Allergy
  • Predominant in GALT
  • Tolerogenic DCs
  • Mast cells, eosinphil, plasma cells
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6
Q

IL-4

A

Th2 (with IL-33)

  • Produce IL-4, IL-5, IL-13
  • Help B cells (IgE)
  • Parasites
  • Allergy
  • Predominant in GALT
  • Tolerogenic DCs
  • Mast cells, eosinphil, plasma cells

Produced by Th2

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7
Q

IL-10

A

Suppressive

Produced by Treg

  • Regulate anti-self responses
  • CD4+, tolerogenic DCs
  • Predominant in GALT
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8
Q

IL-17

A

Produced by Th17

  • Recruit neutrophils
  • Autoimmune damage
  • Barrier integrity
  • Fungi
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9
Q

IFN-Y

A

Antiviral

Produced by Th1

  • Macrophages
  • B cell help (IgG)
  • Inflammation
  • Attack intra and extracellular bacteria
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10
Q

TNF

A

Inflammatory

Produced by Th1

  • Macrophages
  • B cell help (IgG)
  • Inflammation
  • Attack intra and extracellular bacteria
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11
Q

IL-5

A

Produced by Th2

  • Help B cells (IgE)
  • Parasites
  • Allergy
  • Predominant in GALT
  • Tolerogenic DCs
  • Mast cells, eosinphil, plasma cells
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12
Q

IL-21

A

Stimulatory

Produced by TFH

  • Help B cells
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13
Q

T reg

A

Activated by

  • TGFB

Produces

  • TGFB
  • IL-10

Response

  • Regulate anti-self responses
  • CD4+, tolerogenic DCs
  • Predominant in GALT
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14
Q

TH 17

A

Activated by

  • IL-6
  • TGFB

Produces

  • IL-17
  • IL-6

Response

  • Recruit neutrophils
  • Autoimmune damage
  • Barrier integrity
  • Fungi
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15
Q

TH 1

A

Activated by

  • IL-12

Produces

  • IFNY, TNF

Response

  • Macrophages
  • B cell help (IgG)
  • Inflammation
  • Attack intra and extracellular bacteria
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16
Q

TH 2

A

Activated by

  • IL-4, IL-33

Produces

  • IL-4, IL-5, IL-13

Response

  • Help B cells (IgE)
  • Parasites
  • Allergy
  • Predominant in GALT
  • Tolerogenic DCs
  • Mast cells, eosinphil, plasma cells
17
Q

TFH

A

Activated by

  • IL-6

Produces

  • IL-21

Response

  • Help B cells
18
Q

Lysozyme

A

Innate Immune System

  • Disrupts peptidoglycan
19
Q

C-reactive protein

A

Innate Immune System

  • Binds capsule, aids phagocytosis, triggers complement cascade
20
Q

Mannose binding lectin

A

Innate Immune System

  • Binds mannose residues on pathogens, triggers the complement cascade
21
Q

Complement proteins

A

Innate Immune System

  • Pro-enzymes, bind pathogen, trigger cascade of reactions that generate effector molecules against pathogen
22
Q

Classical Complement Pathway

A

Bind to antibody

23
Q

Lectin Complement Pathway

A

Bind to mannan

24
Q

Alternative Complement Pathway

A

Bind to pathogen surfaces

Second Year Microbiology (8 decks)

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