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Immunology Cytokines/Chemokines > Cytokines nd Chemokines > Flashcards

Cytokines nd Chemokines Flashcards

1
Q

BAFF

A

Secreted by myeloid cells in lymphoid follicles and bone marrow
Helps with follicular B cell survival
Co-stimulates switching to IgA

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2
Q

CCL2 (MCP1)

A

Mixed leukocyte recruitment

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3
Q

CCL5(RANTES)

A

Mixed leukocyte recruitment

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4
Q

CXCL8(IL-8)

A

Secreted by endothelial cells

Neutrophil recruitment

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5
Q

CXCL10(IP-10)

A

Secreted by Macrophages, DC’s and T cells

Effector T cell to tissue

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6
Q

CXCL12 (SDF-1alphabeta)

A

Homing naive Cells into LN

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7
Q

CXCL13 (BCA-1)

A

Secreted by Follicular DC’s
Naive B cell migration into follicles of lymph node
T follicular helper cell migration into follicles

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8
Q

CCL19/21

A

Secreted by DC

Activated B cells will express CCR7 which induces migration to T cell zone

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9
Q

INF-gamma

A

Secreted by CD4+ T cells
Activates APCsby inducing expression of costimulatory molecules (CD80/86) as well as MHC expression
Stimulates T cell proliferation
Stimulated IgG production and inhibits Th@ response (IgE)

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10
Q

IL-1

A

Secreted by mast cells and tissue macrophages (remember mast cells are never in circulation)
Induces endothelial cell expression of E-selectin
Can penetrate blood-blain barrier and induce fever
stimulate defensin production

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11
Q

IL-2

A

Secreted by Th1 cells

T Cell proliferation

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12
Q

IL-4

A

Secreted by Th2 Cells
Ig production
stimulated Th2 proliferation

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13
Q

IL-5

A

Secreted by Th2 cells

Activates eosinophils

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14
Q

IL-6

A

Secreted by Macrophages and endothelial class and T cells
Main target is the liver to induce synthesis of acute phase proteins
Also targets B cells for plasma cell differentiation
stimulates defensin production

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15
Q

IL-7

A

Secreted by Stromal Cells
T cell progenitor proliferation
Anti-apoptotic proteins for memory T cells
IL-7R is a phenotypic marker of memory T cells

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16
Q

IL-10

A

Secreted by macrophages DC and Treg Cells
Tissue repair
Regulatory Cytokine

17
Q

IL-12

A

Secreted by macrophages and DC’s
Upregulates NK cell activity and promotes T cell differentiation into Th1 cells which aid with antiviral/intracellular immunity
Differentiation into CD8+ CTL
Induces IFN-gamma production by NK cells and T cells
Survival cytokine for recently activated CTL (need MHC:Ag+costimulatory+IL-12)
Because it induces CTL response, to induces expression of IFN-gamma and TNF-beta by CD4+ and CD8+ cells

18
Q

IL-13

A

Secreted by CD4+ Th2 cells

Mucosus secretion and wound repair by MZ macrophages

19
Q

IL-15

A 
Secreted by DC's and tissue macrophages
NK cell proliferation
Expression of anti-apoptotic proteins in memory T cells
Slow proliferation of memory T cells
Shares gamma chain receptor of IL-2R

Immunology Cytokines/Chemokines (1 decks)

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