Cytokines kinda kinky Flashcards
1
Q
IL-7
A
B and lymphoid cell dev (+IL-3)
HSC
2
Q
M-CSF
A
Macrophage dev
HSC
3
Q
IL-3
A
MPC dev, prolif of myeloid cells
HSC, myeloid cells (granulocytes, monocytes, DCs)
4
Q
Epo
A
RBC dev
HSC
5
Q
G-CSF
A
Neutrophil dev
HSC
6
Q
IL-1
A
Expression of P,E selectins on endothelial cells
Secreted by Macrophages
7
Q
TNF-a
A
Expression of P,E selectins on endothelial cells
Inflammatory
Secreted by Macrophages
8
Q
IL-4
A
IgE class switching and somatic hypermutation CD4+ T cells, basophils
9
Q
IF-gamma
A
IgG class switching
10
Q
TGF-beta
A
IgA class switching, anti-inflammatory
11
Q
IL-10
A
Anti-Inflammatory
12
Q
IL-6
A
Inflammatory
13
Q
IL-12
A
inflammatory, activate naïve T cells
APCs
14
Q
IL-2
A
T cell prolif
produced by activated T cells
15
Q
IL-17
A
Inflammatory
Th17 CD4+ T cells
16
Q
IL-22
A
Promotes epithelial barrier functions
Th17 CD4+ T cells
17
Q
TNF-a
A
Upregulates endothelial adhesion molecules to help immune cells cross
