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Renal Test 2 > Cytokines, Interferons, Etc. > Flashcards

Cytokines, Interferons, Etc. Flashcards

1
Q

what is secreted by M2 macs

A

IL-10
TGF-Beta
**these cause RENAL FIBROSIS + ANTI-INFLAMMATION

TFG-Beta
Proline Polyamine
**these cause RENAL FIBROSIS + WOUND REPAIR

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2
Q

IL-6

A

DAMP/PAMP mediator
mac
kidney Ds

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3
Q

what releases chemokines

A

M1 macs

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4
Q

T-cell + IL-12 = ???

A

Th1 cells

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5
Q

macs associated with IFN-gamma

A

M1 macs

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6
Q

function of IL-17

A

tissue inflammation

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7
Q

what releases IL-4

A

Th2 cells (humoral immunity)

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8
Q

what secretes IL-17

A

Th17 cells

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9
Q

T-cell + IL-4

A

Th2 cells

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10
Q

macs associated with IL-4 macs

A

M2 macs

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11
Q

TNF

A

macs

kidney Ds

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12
Q

what to Th17 cells release

A

IL-17

CCL20 (also called MIP-3)

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13
Q

what secretes TNF-beta

A

T-reg cells

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14
Q

pro-inflammatory substances

A
  1. DCs
  2. Macs (M1)
  3. T-cells
  4. Th1
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15
Q

IL-10 function

A

anti-inflammatory

tissue repair (AKI repair)

M2 macs

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16
Q

function of CCL20 cells

A

recruit: monocytes, Th1 cells, Th17 cells

pro-inflammation

17
Q

what secretes IL-5

A

Th2 cells

18
Q

macs associated with IL-13

A

M2 macs

19
Q

what releases IL-13

A

Th2 cells (humoral immunity)

20
Q

IL-1B

A

DAMP/PAMP mediator
mac
kidney Ds

21
Q

Fxn of TNF-beta cells

A

wound repair

renal fibrosis

22
Q

DAMP/PAMP Mediator

A

TNF-alpha
IL-1B
IL-6

23
Q

another name for CCL20

A

MIP-3

macrophage inflammatory protein-3

24
Q

what secretes IL-10

A

T reg cells

25
Q

what is secreted by M1 macs

A 
IL-1
IL-12
IL-23
chemokines
****these cause INFLAMMATION

ROS
NO
Lysosomal enzymes
*****these cause PHAGOCYTOSIS & KILLING

26
Q

fxn of osteopontin and ICAM-1

A

release adhesion and pro-inflammatory activators

27
Q

what do Th1 cells release

A

IFN-gamma

28
Q

what releases IFN-gamma

A

Th1 cells (cellular host v. graft rejection)

29
Q

what secretes CCL20

A

Th17 cells

30
Q

T-cell + (TFG-B + IL-6)

A

Th17

31
Q

Anti-inflammatory substances

A
  1. Macs (M2)
  2. T-cells
  3. Arginase-1
32
Q

what do Th2 cells release

A

IL-4
IL-5
IL-13

33
Q

IL-10 is associated with what type of rejection

A

humoral host v. graft rejection

34
Q

monocytes + ?????? = M2 macs

A

IL-4

IL-13

35
Q

monocytes + ????? = M1 macs

A

IFN-gamma & TLR-ligand

36
Q

what secretes ROS

A

macs

37
Q

what causes M1 macs to transform into M2 macs

A

CSF-1 (M-CSF)

IL-10

38
Q

IL-5 associated w/what type of rejection

A

humoral host v. graft rejection

39
Q

type of rejection associated with IL-2

A

humoral host v. graft rejection via Th1

Renal Test 2 (9 decks)

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