Cytokines, Interferons, Etc.

Question 1

what is secreted by M2 macs

Answer 1

IL-10
TGF-Beta
**these cause RENAL FIBROSIS + ANTI-INFLAMMATION

TFG-Beta
Proline Polyamine
**these cause RENAL FIBROSIS + WOUND REPAIR

Question 2

IL-6

Answer 2

DAMP/PAMP mediator
mac
kidney Ds

Question 3

what releases chemokines

Answer 3

M1 macs

Question 4

T-cell + IL-12 = ???

Answer 4

Th1 cells

Question 5

macs associated with IFN-gamma

Answer 5

M1 macs

Question 6

function of IL-17

Answer 6

tissue inflammation

Question 7

what releases IL-4

Answer 7

Th2 cells (humoral immunity)

Question 8

what secretes IL-17

Answer 8

Th17 cells

Question 9

T-cell + IL-4

Answer 9

Th2 cells

Question 10

macs associated with IL-4 macs

Answer 10

M2 macs

Question 11

TNF

Answer 11

macs

kidney Ds

Question 12

what to Th17 cells release

Answer 12

IL-17

CCL20 (also called MIP-3)

Question 13

what secretes TNF-beta

Answer 13

T-reg cells

Question 14

pro-inflammatory substances

Answer 14

1. DCs
2. Macs (M1)
3. T-cells
4. Th1

Question 15

IL-10 function

Answer 15

anti-inflammatory

tissue repair (AKI repair)

M2 macs

Question 16

function of CCL20 cells

Answer 16

recruit: monocytes, Th1 cells, Th17 cells

pro-inflammation

Question 17

what secretes IL-5

Answer 17

Th2 cells

Question 18

macs associated with IL-13

Answer 18

M2 macs

Question 19

what releases IL-13

Answer 19

Th2 cells (humoral immunity)

Question 20

IL-1B

Answer 20

DAMP/PAMP mediator
mac
kidney Ds

Question 21

Fxn of TNF-beta cells

Answer 21

wound repair

renal fibrosis

Question 22

DAMP/PAMP Mediator

Answer 22

TNF-alpha
IL-1B
IL-6

Question 23

another name for CCL20

Answer 23

MIP-3

macrophage inflammatory protein-3

Question 24

what secretes IL-10

Answer 24

T reg cells

Question 25

what is secreted by M1 macs

Answer 25

``` IL-1 IL-12 IL-23 chemokines ****these cause INFLAMMATION ``` ROS NO Lysosomal enzymes *****these cause PHAGOCYTOSIS & KILLING

Question 26

fxn of osteopontin and ICAM-1

Answer 26

release adhesion and pro-inflammatory activators

Question 27

what do Th1 cells release

Answer 27

IFN-gamma

Question 28

what releases IFN-gamma

Answer 28

Th1 cells (cellular host v. graft rejection)

Question 29

what secretes CCL20

Answer 29

Th17 cells

Question 30

T-cell + (TFG-B + IL-6)

Answer 30

Th17

Question 31

Anti-inflammatory substances

Answer 31

1. Macs (M2) 2. T-cells 3. Arginase-1

Question 32

what do Th2 cells release

Answer 32

IL-4 IL-5 IL-13

Question 33

IL-10 is associated with what type of rejection

Answer 33

humoral host v. graft rejection

Question 34

monocytes + ?????? = M2 macs

Answer 34

IL-4 | IL-13

Question 35

monocytes + ????? = M1 macs

Answer 35

IFN-gamma & TLR-ligand

Question 36

what secretes ROS

Answer 36

macs

Question 37

what causes M1 macs to transform into M2 macs

Answer 37

CSF-1 (M-CSF) | IL-10

Question 38

IL-5 associated w/what type of rejection

Answer 38

humoral host v. graft rejection

Question 39

type of rejection associated with IL-2

Answer 39

humoral host v. graft rejection via Th1