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Immunology > Cytokines, Chemokines, Igs And Adhesion Molecules > Flashcards

Cytokines, Chemokines, Igs And Adhesion Molecules Flashcards

1
Q

Primary inflammation
Activation of neutrophils
Induction of adhesion molecules

A

TNF

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2
Q

Thermoregulation/fever

Slow inflammation

A

IL-1

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3
Q

Produces INF-gamma from NK cells

A

IL-12

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4
Q

Major producer of APPs

Inflammation

A

IL-6

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5
Q

Not produced by macrophages but instead NK cells

Activates macrophages

A

INF-gamma

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6
Q

Lymphocyte/DC recruitment to HEVs

Control of inflammation (anti)

A

IL-10

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7
Q

Neutrophil recruitment

Conformational change in surface molecules for migration into tissue

A

IL-8 also known CxCL8

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8
Q

3 cytokines that work with proliferation of immunoglobins/T0cells and isotype switching

A

IL-2,4, and 5

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9
Q

Cytokine that associates with IgM

A

IL-2,4,5

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10
Q

Cytokine that that associates with IgE and IgG1

A

IL-4

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11
Q

Cytokine that associates with IgG3 and IgG2a

A

INF-gamma

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12
Q

Cytokine that associates with IgA and IgG2b

A

TGF-beta

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13
Q

Chemokine for monocyte recruitment

A

CCL2/MPC-1

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14
Q

Chemokine for T-cell, DC, NK monocyte recruitment

A

CCL4 (MIP-1beta)

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15
Q

2 chemokines for migration to parafillicular zones

A

CCL19 (MIP-3beta), CCL21 (SLC)

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16
Q

Chemokine serves as effector T-cell recruitment

Activates integrins and other chemokines

A

CxCL10 (IP-10)

17
Q

Chemokine for hominv naive B-cells to LN

A

CxCL12 (SDF-1alphabeta)

18
Q

Chemokine for B-cell migration and T-follicular helper cell migration into follicles

A

CxCL13 (BCA-1)

19
Q

Immunoglobulin for neutralization in mucosal secretions; TGF-beta cytokine

A

IgA

20
Q

Immunoglobulin complement activator; in plasma

A

IgM - default

21
Q

Immunoglobulin B-cell receptor

A

IgD

22
Q

Immunoglobulin that Penetrates deep tissue, works with complement and neutralization

A

IgG

23
Q

Helminth defense/allergies and mast cell surfaces; IL4 cytokine

A

IgE

24
Q

Peripheral selectin that acts by histamine and thrombin

A

P-selectin (CD62P)

25
Q

Peripheral selectin that acts by TNF/IL-1

A

E-selectin (CD63E)

26
Q

Selectin that works with neutrophils, monocytes, T and B cells; adhesion to HEV on LN

A

L-selectin

27
Q

Integrin
ICAM1 and 2
Lymphocyte function

A

LFA-1

28
Q

Integrin
ICAM1 and 2
Macrophage antigen

A

Mac-1

29
Q

Integrin
Very late ag
VCAM1

A

VLA-4

30
Q

Integrin
VCAM1 and MadCAM1
Mucosal addresin

A

Alpha4beta7

31
Q

Cytokine for B-cell responses

Required for proliferation and isotype switching

A

IL-4

32
Q

Works with innate immunity and acts as a stimulant for tissue remodeling via fibroblasts and chemoattractants

A

TGF-beta

Immunology (2 decks)

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