Cytokines-cellular messengers Flashcards
Cytokine size and solubility
30Kd soluble in water
What type of biomolecule are they
proteins and cytokines
Who are the main producers
Lymphocytes and monocytes
What are cytokines from lymphocytes called
Interleukins
What are cytokines from monocytes called
Monokins
How do they carry out their effect
Through interaction with cell receptor leading to signal transduction and cellular response
General idea of what cytokines do
Cytokines are basically the immune systems hormones, they are involved in immune system regulation and inflammation regulation
is cytokine effect long lasting or short lasting, and is the synthesis induced or constant
Short lasting, the have a short half-life, there synthesis is induce by stimulation and doesn’t cease until simulation stops
chemotactic cytokines also known as
Chemokines
Cytokine modulation
cytokines help modulate the type of immune response (Th1 or Th2), the extent of the response and the duration of the response
Cytokine regulation
Cytokines regulate hematopoiesis, the innate immune system through inflammation and chemotaxis and the adaptive immune system through t and b cell activation
Who produces IL-2 what response is it mainly involved in ?
CD4 plus T lymphocytes mainly involve in adaptive immune responses
Class 1 and Class 2 cytokine receptors
class one are the hematopoietic receptor family and class 2 are the interferon receptor family
name all families of cytokine receptors
Hematopoietic, Interferon, immunoglobin, growth factors, TNF and chemoquine receptor family
IL-1 primary function and secondary functions
Primary its a proinflammatory drug, but IL-1 can also Act on on liver leading to production of acute phase protein like the c reactive protein, complement proteins, fibrinogen e. On brain (hypothalamus) it induces the hyperthermia, on endothelial tissue it promotes chemotaxis, on epithelial tissue promotes release of prostaglandins(fever), and on mast cells it triggers release of histamine
