Cytokines And Random Immuno Things Flashcards
C5a
Chemotactic for neutrophils
C3a and C5a
Trigger mast cell degranulation resultin fin histamine mediated vasodilation and increased vascular permeability
MAC
Lyses microbes by creating a hole in cell membrane
C3b
Opsonins for phagocytosis
Tells neutrophils what to consume
clear immune complexes
Main pain causers in inflammation.
Bradykinin and PGE2 sensitize sensory nerve endings
Antiinflammatory cytokines
IL-10 and TGF-B
Neutrophils activated by
LTB4
C5a
Il-8
Bacterial products
IL-1
Secreted by macrophages
Causes fever, acute inflammation
Activates endothelium to produce adhesion molecules
IL-2
Secreted by T-cells
Stimulates growth dl helper, cytotoxic and regulatory T cells
IL-3
Secreted by T cells
Supports growth and differentiation of bone marrow stem cells
IL-4
Secreted by TH2 cells
Induces differentiation into Th2 cells
Promotes growth of B cells
Enhances class switching to IgE and IgG
IL-5
Promotes differentiation of B cells
Enhances class switching to IgA
Stimulates growth and differentiation of eosinophils
IL-6
Secreted by macrophages and Th2 cells
Causes fever and production of acute phase proteins
IL-8
Secreted by macrophages
Chemotactic for neutrophils
IL-10
Secreted from TH2 cells and Treg cells
Modulates inflammatory response
Inhibits actions of activated Tcells and TH1
TNF-alpha
Secreted by macrophages
Mediates septic shock
Activates endothelium
Causes leukocyte recruitment, vascular leak
IFN-gamma
Secreted by TH1 cells
Antiviral and anti tumors properties
Activates NK cells to kill virus infected cells
Increases MHC expression and Ag presentations all cells
IgD
Activates naive B cells
IgM
Activates naive B cells Immediate response to Ag Neutralize mucus, tears, breast milk Activates complement
IgG
Serum higher concentration Longest half-life in serum delayed response to Ag Neutralizes bacterial toxins and viruses Opsonizes Activates NK cells Activates Complement Enters fetal circulation
IgA
2/3 of total Ig in an individual Neutralizes Mucus, tears, breast milk and sweat Prevents bacteria and vrisuses to mucous membranes Crosses epithelial cells by transcytosis
IgE
Binds mast cells and basophils Cross links when exposed to allergen leading to Type I hypersensitivity Mediates immunity to worms Lowest concentration in serum Neutralizes Allergic reaction
RAG
bind gene segments, cut the DNA and join the gene segments to produce unique light and heavy chains
B2 microglobulin
transports MHCI to plasma membrane in exocytic vesicle to present to CD8+ cells
