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ID Domain > Cytokines And Random Immuno Things > Flashcards

Cytokines And Random Immuno Things Flashcards

0
Q

C5a

A

Chemotactic for neutrophils

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1
Q

C3a and C5a

A

Trigger mast cell degranulation resultin fin histamine mediated vasodilation and increased vascular permeability

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2
Q

MAC

A

Lyses microbes by creating a hole in cell membrane

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3
Q

C3b

A

Opsonins for phagocytosis
Tells neutrophils what to consume
clear immune complexes

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4
Q

Main pain causers in inflammation.

A

Bradykinin and PGE2 sensitize sensory nerve endings

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5
Q

Antiinflammatory cytokines

A

IL-10 and TGF-B

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6
Q

Neutrophils activated by

A

LTB4
C5a
Il-8
Bacterial products

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7
Q

IL-1

A

Secreted by macrophages
Causes fever, acute inflammation
Activates endothelium to produce adhesion molecules

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8
Q

IL-2

A

Secreted by T-cells

Stimulates growth dl helper, cytotoxic and regulatory T cells

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9
Q

IL-3

A

Secreted by T cells

Supports growth and differentiation of bone marrow stem cells

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10
Q

IL-4

A

Secreted by TH2 cells
Induces differentiation into Th2 cells
Promotes growth of B cells
Enhances class switching to IgE and IgG

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11
Q

IL-5

A

Promotes differentiation of B cells
Enhances class switching to IgA
Stimulates growth and differentiation of eosinophils

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12
Q

IL-6

A

Secreted by macrophages and Th2 cells

Causes fever and production of acute phase proteins

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13
Q

IL-8

A

Secreted by macrophages

Chemotactic for neutrophils

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14
Q

IL-10

A

Secreted from TH2 cells and Treg cells
Modulates inflammatory response
Inhibits actions of activated Tcells and TH1

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15
Q

TNF-alpha

A

Secreted by macrophages
Mediates septic shock
Activates endothelium
Causes leukocyte recruitment, vascular leak

16
Q

IFN-gamma

A

Secreted by TH1 cells
Antiviral and anti tumors properties
Activates NK cells to kill virus infected cells
Increases MHC expression and Ag presentations all cells

17
Q

IgD

A

Activates naive B cells

18
Q

IgM

A 
Activates naive B cells
Immediate response to Ag
Neutralize
mucus, tears, breast milk
Activates complement
19
Q

IgG

A 
Serum higher concentration
Longest half-life in serum
delayed response to Ag
Neutralizes bacterial toxins and viruses
Opsonizes
Activates NK cells
Activates Complement 
Enters fetal circulation
20
Q

IgA

A 
2/3 of total Ig in an individual
Neutralizes
Mucus, tears, breast milk and sweat
Prevents bacteria and vrisuses to mucous membranes
Crosses epithelial cells by transcytosis
21
Q

IgE

A 
Binds mast cells and basophils
Cross links when exposed to allergen leading to Type I hypersensitivity
Mediates immunity to worms
Lowest concentration in serum 
Neutralizes 
Allergic reaction
22
Q

RAG

A

bind gene segments, cut the DNA and join the gene segments to produce unique light and heavy chains

23
Q

B2 microglobulin

A

transports MHCI to plasma membrane in exocytic vesicle to present to CD8+ cells

24
Q

IFN-a and B

A

Innate host defense against RNA and DNA viruses
synthesized by viral infected cells and act on local uninfected cells “priming” them for viral defense
RNAase L-degrades viral/host mRNA
Protein kinase inhibits viral/host protein synthesis
Resulting in apoptosis
IFN-alpha from macrophages
IFN-beta from fibroblasts

25
Q

CRP

A

C reactive protein
Opsonin: fixes complement and facilitates phagocytosis
sign of ongoing inflammation

26
Q

IL-13

A

Stimulates mast cell proliferation

27
Q

AID

A

Key enzyme in isotype switching

28
Q

IL-7

A

Bone marrow stromal cells

T cell and B cell progenitor differentiation

29
Q

IL-12

A

Secreted by macrophages to CD4+ to differentiate into TH1 subtype in chronic granulomatous formation
TH1 then secretes IFN-gamma to recruit more macrophages

30
Q

Acute phase reactants

A

Serum concentrations change significanly in response to inflamamtion

Produced in the liver in both acute and chronic inflammatory states

Induced by IL-6, IL-1, TNF-a and IFN-y

31
Q

Serum amyloid A

A

Acute phase reactant

Prolonged elevation can lead to amyloidosis

32
Q

Ferritin

A

Acute phase reactant

Binds and sequesters iron to inhibit microbial iron scavenging

33
Q

Fibrinogen

A

Acute phase reactant

Promotes endothelial repair

Correlates with ESR

34
Q

Hepcidin

A

Acute phase reactant

Prevents release of iron bound by ferritin

35
Q

Decaying accelerating factor (CD55)

A

Prevent complement activation on self cells

36
Q

C1 esterase inhibitor

A

Prevent complement activation on self cells

ID Domain (2 decks)

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