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Host Defense > Cytokines and CD Markers > Flashcards

Cytokines and CD Markers Flashcards

1
Q

Granulocyte

A

CD15+

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2
Q

Monocyte

A

CD14+

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3
Q

Dendritic Cell

A

CD11c

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4
Q

T Lymphocyte

A

CD3+

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5
Q

T Helper Lymphocyte

A

CD3+, CD4+
Recongnize MHC II

Produce Cytokines

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6
Q

T Cytotoxic Lymphocyte

A

CD3+, CD8+

Recognize MHC I

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7
Q

B Lymphocyte

A

CD19+

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8
Q

Natural Killer Cell

A

CD56+

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9
Q

Common myeloid progenitor

A

gives rise to cells of myeloid origin (mast, basophil, neutrophil, eosinophil, maccrophage)

Cytokine signal: HSC—————-> common myloid
- IL-3
-SCF
GM-CSF

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10
Q

IL-1, IL-6, TNFα

A

Pro-inflammatory cytokines, released by macrophages.

Swelling, fever

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11
Q

IFNγ

A

pro-inflammatory, activate DC

produced by Type 1 ILC (NK, NKT)

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12
Q

IL-4

A

help maturation of DC

produced by Type II ILC

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13
Q

IL-17

A

recruit neutrophils, induce antimicrobial peptides

produced by Type III ILC

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14
Q

IL-1, IL-6, IL-7, SCF, TSLP

A

cytokines released by Thymic Epithelial Cells that are required for growth/development of T cells

SCF: (stem cell factor)
TSLP: (thymic stroma lymphoprotein)

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15
Q

IL-10

A

Immunonsuppressive

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16
Q

Mutation FOX P3

A

No Treg

17
Q

AIRE

A

TF neccessary for the generation of central tolerance

18
Q

NKT Cells

A

CD4+ or CD4-/CD8-

Express CD56

19
Q

CD45

A

Distinguish Naive and Memory T cells by CD45 marker

CD45RA- naive (RA’s at camp are young)
CD45RO- memory (really old, been around)

20
Q

INF-gamma

A

potent pro-inflammatory
Th1 signature cytokine: Intracellular pathogen
activates Macrophages

21
Q

IL-2

A

T cell growth factor (Th1 and CD8)
Th1 cytokine

The receptor, IL-2R (alpha-beta-gamma) has HIGH affinity for IL-2, shown on activated T cell

Genetic mutation in the gamma chain of IL-2R results in severe immune deficiency

22
Q

LT alpha

A

Lymphotoxin-alpha
TNF family. Th1 cytokine.
Maintains lymphoid organ development

Implicated in RA, MS

23
Q

Th1

A

INF-gamma and IL-12
TF: Tbet

Th1 produces INF-gamma, IL-2, LT-alpha
activates macrophages

Activated macrophages make IL-1, IL-6, IL-8, TNF-alpha: ALL PRO-INFLAMMATORY

24
Q

IL-1

A

Pro-inflammatory:
response to stress, made by epithelial cells, neutrophil growth and liberation from marrow, increase Ag presentation

IL-1 and IL-6 cause fever, depression

25
Q

IL-6

A

Pro-inflammatory:
growth/differentiation of B cells, increases responsiveness to IL-2 (Tcell growth factor), release Ca

WIL-1 and IL-6 cause fever, depression

26
Q

IL-8

A

POTENT for mobilizing and recruiting neurophils (killers) and eosinophils

Produced by macs and neutrophils and epithelium (when intense inflammation)

27
Q

IL-4

A

Initiates and is required for Th2
growth factor for Th2 cells
promotes B cell growth,
IL-4 inhibits Th1

IL-4 and IL-13: recruit eosinophil, basophil, allergic asthma, make memory B cells

28
Q

IL-5

A

eosinophil maturation (kill parasite)

29
Q

IL-10

A

drives B cell differentiation, inhibits Th1 (inhibits pro-inflammatory cytokines)
(also produced by iTreg and Thf)

30
Q

IL-17

A

Key cytokine in Th-17 response to fungi, extracellular

  • recruit and activate neutrophils and monocytes
  • educe pro-inflammatory IL-6, IL-8
31
Q

IL-21

A

enhance B cell function

Contributes to Ab mediated pathology, ie Hyper IgE: recurrent Staph and fungal infection

32
Q

IL-22

A

protective gut immunity, keeps good bacteria in their niches by induction of antimicrobial peptides

33
Q

Thf

A

fully mature Thf are in follicle germinal centers, causing B cells to become Plasma Cells ad secrete Ab (IgM, IgG, IgA)

Chemokine CXCR5 is important, brings Thf to follicle

IL-4 (Bcell growth, inhibit Th1, anti-inflammatory),
IL-10 (Bcell diffenrtiaiton, inhibit Th1, anti-inflamm),
IL-21 (Bcell Funftion)
* All cytokines help B cells become Plasma*

Host Defense (1 decks)

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