Cytokines and CD Markers Flashcards
Granulocyte
CD15+
Monocyte
CD14+
Dendritic Cell
CD11c
T Lymphocyte
CD3+
T Helper Lymphocyte
CD3+, CD4+
Recongnize MHC II
Produce Cytokines
T Cytotoxic Lymphocyte
CD3+, CD8+
Recognize MHC I
B Lymphocyte
CD19+
Natural Killer Cell
CD56+
Common myeloid progenitor
gives rise to cells of myeloid origin (mast, basophil, neutrophil, eosinophil, maccrophage)
Cytokine signal: HSC—————-> common myloid
- IL-3
-SCF
GM-CSF
IL-1, IL-6, TNFα
Pro-inflammatory cytokines, released by macrophages.
Swelling, fever
IFNγ
pro-inflammatory, activate DC
produced by Type 1 ILC (NK, NKT)
IL-4
help maturation of DC
produced by Type II ILC
IL-17
recruit neutrophils, induce antimicrobial peptides
produced by Type III ILC
IL-1, IL-6, IL-7, SCF, TSLP
cytokines released by Thymic Epithelial Cells that are required for growth/development of T cells
SCF: (stem cell factor)
TSLP: (thymic stroma lymphoprotein)
IL-10
Immunonsuppressive
Mutation FOX P3
No Treg
AIRE
TF neccessary for the generation of central tolerance
NKT Cells
CD4+ or CD4-/CD8-
Express CD56
CD45
Distinguish Naive and Memory T cells by CD45 marker
CD45RA- naive (RA’s at camp are young)
CD45RO- memory (really old, been around)
INF-gamma
potent pro-inflammatory
Th1 signature cytokine: Intracellular pathogen
activates Macrophages
IL-2
T cell growth factor (Th1 and CD8)
Th1 cytokine
The receptor, IL-2R (alpha-beta-gamma) has HIGH affinity for IL-2, shown on activated T cell
Genetic mutation in the gamma chain of IL-2R results in severe immune deficiency
LT alpha
Lymphotoxin-alpha
TNF family. Th1 cytokine.
Maintains lymphoid organ development
Implicated in RA, MS
Th1
INF-gamma and IL-12
TF: Tbet
Th1 produces INF-gamma, IL-2, LT-alpha
activates macrophages
Activated macrophages make IL-1, IL-6, IL-8, TNF-alpha: ALL PRO-INFLAMMATORY
IL-1
Pro-inflammatory:
response to stress, made by epithelial cells, neutrophil growth and liberation from marrow, increase Ag presentation
IL-1 and IL-6 cause fever, depression
IL-6
Pro-inflammatory:
growth/differentiation of B cells, increases responsiveness to IL-2 (Tcell growth factor), release Ca
WIL-1 and IL-6 cause fever, depression
IL-8
POTENT for mobilizing and recruiting neurophils (killers) and eosinophils
Produced by macs and neutrophils and epithelium (when intense inflammation)
IL-4
Initiates and is required for Th2
growth factor for Th2 cells
promotes B cell growth,
IL-4 inhibits Th1
IL-4 and IL-13: recruit eosinophil, basophil, allergic asthma, make memory B cells
IL-5
eosinophil maturation (kill parasite)
IL-10
drives B cell differentiation, inhibits Th1 (inhibits pro-inflammatory cytokines)
(also produced by iTreg and Thf)
IL-17
Key cytokine in Th-17 response to fungi, extracellular
- recruit and activate neutrophils and monocytes
- educe pro-inflammatory IL-6, IL-8
IL-21
enhance B cell function
Contributes to Ab mediated pathology, ie Hyper IgE: recurrent Staph and fungal infection
IL-22
protective gut immunity, keeps good bacteria in their niches by induction of antimicrobial peptides
Thf
fully mature Thf are in follicle germinal centers, causing B cells to become Plasma Cells ad secrete Ab (IgM, IgG, IgA)
Chemokine CXCR5 is important, brings Thf to follicle
IL-4 (Bcell growth, inhibit Th1, anti-inflammatory),
IL-10 (Bcell diffenrtiaiton, inhibit Th1, anti-inflamm),
IL-21 (Bcell Funftion)
* All cytokines help B cells become Plasma*
