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Micro > Cytokines > Flashcards

Cytokines Flashcards

1
Q

IL-1 alpha and beta

A

. Produced by macrophages ad epithelial cells

. Induce fever, pro inflammatory

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2
Q

IL-2

A

. Produced by T cells

. Works as growth factor

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3
Q

IL-4

A

. Produced by Th2 cells and mast cells
. Promotes Th2 differentiation, B cel activation
. B cell switch to IgE promotes eosinophilia

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4
Q

IL-5

A

. Produced by Th2 cells and mast cells

. Promotes eosinophilia

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5
Q

IL-6

A

. Produced by Th2 cells, macrophages, and endothelial cells

. Promotes T and B cell growth, acute phase protein production, and induce fever

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6
Q

IL-7

A

. Produced by stromal cells

. Promotes development of B and T cell progenitors

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7
Q

IL-8

A

. Produced by macrophages, endothelial/epithelial cells

. It is a chemo tactic factor for neutrophils and other granulocytes

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8
Q

IL-10

A

. Produced by monocytes, T cells, and certain B cell subsets
. Suppresses macrophages and. CTL
. Acts as B cell growth factor

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9
Q

IL-12

A

. Produced by macrophages and dendritic cells

. Promotes Th1 differentiation and activates NK cells

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10
Q

IL-13

A

. Produced by Th2 cells

. Promotes T and B cell growth, acute phase protein production, induces fever, and inhibits macrophages

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11
Q

IL-17

A

. produced by Th17 cells

. Inc. neutrophil production, pro inflammatory

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12
Q

IL-21

A

. Produced by Th17 cells

. Causes proliferation of B, T, and NK cells

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13
Q

IL-22

A

. Produced by NK cells and Th17 cells

. Induces acute phase proteins, pro-inflammatory

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14
Q

IL-23

A

. Produced by dendritic cells, monocytes/macrophages

. Promotes the development and proliferation of Th17 cells

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15
Q

TNF-alpha

A

. Produced by macrophages, NK, and T cells

. Promotes inflammation

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16
Q

Lymphotoxin-alpha

A

. Produced by T and B cells

. Induces apoptosis of target cells

17
Q

BAFF (Blys)

A

. Produced by B cells

. Induces B cell proliferation, maturation, and survival

18
Q

TGF-beta1

A

. Produced by monocytes, T cells, and certain B cell subsets

. Inhibits cell growth, anti-inflammatory, and promotes IgA switch

19
Q

IFN-alpha

A 
. Produced by all nucleated cells 
. Anti-viral, inc. HLA class 1 expression
20
Q

IFN-beta

A 
. Produced by fibroblasts 
. Anti-viral, inc. HLA class I expression
21
Q

IFN-gamma

A

. Produced by T cells and NK cells

. Inc. macrophage activation, HLA I and II expression

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