Cytokines Flashcards
0
Q
IL-2
A
Stimulate all T cell growth
-Secreted by all T cells
1
Q
IL-1
A
Fever, inflammation
- Secreted by macrophages
- activates endothelial adhesion
- recruits leukocytes
2
Q
IL-3
A
Stimulate bone marrow
- Secreted by all T cells
- GM-CSF like function (stimulate bone marrow stem cells)
3
Q
IL-4
A
Stimulate IgE
- Secreted by Th2 cells
- promotes B cell switching to IgE, IgG
- promotes Th2 differentiation
4
Q
IL-5
A
Stimulate IgA
- Secreted by Th2 cells
- promotes B cell to IgA switching
- promotes eosinophil growth
5
Q
IL-6
A
Fever and acute-phase proteins
-Secreted by macrophages, Th2 cells
6
Q
IL-8
A
Chemotactic factor for neutrophils
-Secreted by macrophages
7
Q
IL-10
A
Inhibits inflammation, Th1
- Secreted by Th2 & regulatory T cells
- similar to TGF-B
8
Q
IL-12
A
Th1, NK cell activation
-Secreted by macrophages, B cells
9
Q
TNF-A
A
Septic shock
- Secreted by macrophages
- vascular leak, leukocyte recruitment
10
Q
IFN-A
A
Induce ribonuclease that degrades viral mRNA, inhibits viral protein synthesis
11
Q
IFN-Y
A
Induce MHC-1,2 expression & antigen presentation on all cells
