Cytokines Flashcards
IL-1
fever (hot), inflammation, T17
IL-2
T cell stimulation
IL-3
Bone marrow stimulator
IL-4
IgE, Th2, activates eosinophils, activates type 2 macrophages
IL-5
IgA
IL-6
Acute phase proteins, T17, plasma cells
IL-7
B/T cell growth
IL-8
chemoattractant
IL-10
Anti-inflammatory
IL-12
Th1, IFN, inflammation
IL-13
IgE, activates type 2 macrophages
IL-15
T cell growth factor, activates natural killer cells
IL-17
inflammation
IL-18
IFNgamma synthesis
IL-22
inflammation, maintains epithelial barrier
IL-23
inflammation
IL-21
T cell differentiation
IFNgamma
Activates Th1 and type 1 macrophages, stimulates class switching and complement binding, stimulates MHC II expression
TGFbeta
Anti-inflammatory, inhibits T cell activation
IFNalpha/beta
Activates natural killer cells, antiviral
FcgammaR1
Activates phagocytes
FcgammaRIIA
phagocytosis
FcgammaRIIB
Feedback inhibition of B cells after inflammation
FcgammaRIIIA
Ab-dependent cell cytotoxicity
FcERI
Activates mast cells and basophils
NKfB
Promotes cytokine production, adhesion molecules
TNFalpha
stimulates ICAM, VCAM, E selectin, fever, vascular endothelium
CD-14
Binds LPS
CD3
Signal transduction on T cells
CD4
Signal transduction on CD4 cells
CD8
Signal transduction on CD8 cells
CD28
Costimulatory on T cells
CTLA-4
Signal inhibition on T cells
PD-1
Signal inhibition on T cells
LFA-1
Adhesion on T cells
CD27
Differentiation of affector T cells
