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MCM final > Cytokines > Flashcards

Cytokines Flashcards

1
Q

IL-1

A

fever (hot), inflammation, T17

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2
Q

IL-2

A

T cell stimulation

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3
Q

IL-3

A

Bone marrow stimulator

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4
Q

IL-4

A

IgE, Th2, activates eosinophils, activates type 2 macrophages

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5
Q

IL-5

A

IgA

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6
Q

IL-6

A

Acute phase proteins, T17, plasma cells

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7
Q

IL-7

A

B/T cell growth

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8
Q

IL-8

A

chemoattractant

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9
Q

IL-10

A

Anti-inflammatory

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10
Q

IL-12

A

Th1, IFN, inflammation

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11
Q

IL-13

A

IgE, activates type 2 macrophages

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12
Q

IL-15

A

T cell growth factor, activates natural killer cells

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13
Q

IL-17

A

inflammation

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14
Q

IL-18

A

IFNgamma synthesis

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15
Q

IL-22

A

inflammation, maintains epithelial barrier

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16
Q

IL-23

A

inflammation

17
Q

IL-21

A

T cell differentiation

18
Q

IFNgamma

A

Activates Th1 and type 1 macrophages, stimulates class switching and complement binding, stimulates MHC II expression

19
Q

TGFbeta

A

Anti-inflammatory, inhibits T cell activation

20
Q

IFNalpha/beta

A

Activates natural killer cells, antiviral

21
Q

FcgammaR1

A

Activates phagocytes

22
Q

FcgammaRIIA

A

phagocytosis

23
Q

FcgammaRIIB

A

Feedback inhibition of B cells after inflammation

24
Q

FcgammaRIIIA

A

Ab-dependent cell cytotoxicity

25
Q

FcERI

A

Activates mast cells and basophils

26
Q

NKfB

A

Promotes cytokine production, adhesion molecules

27
Q

TNFalpha

A

stimulates ICAM, VCAM, E selectin, fever, vascular endothelium

28
Q

CD-14

A

Binds LPS

29
Q

CD3

A

Signal transduction on T cells

30
Q

CD4

A

Signal transduction on CD4 cells

31
Q

CD8

A

Signal transduction on CD8 cells

32
Q

CD28

A

Costimulatory on T cells

33
Q

CTLA-4

A

Signal inhibition on T cells

34
Q

PD-1

A

Signal inhibition on T cells

35
Q

LFA-1

A

Adhesion on T cells

36
Q

CD27

A

Differentiation of affector T cells

MCM final (2 decks)

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