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Alikhan Review of Dermatology > Cytokines > Flashcards

Cytokines Flashcards

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Dermatology Board Prep flashcards
1
Q

What is the immune system source and the principle effects of IL-1a, IL-1b

A

Produced from Macrophages, B-cells, keratinocytes

Effects: Increased production of acute phase proteins, fever, lymphocyte activation macrophage activation, increased leukocyte/endothelial adhesion; involved in innate immunity inflammatory responses

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2
Q

What is the immune system source and the principle effects of IL-2

A

T-cells

effects: proliferation of T-, B-, and NK- cells; T-cell differentiation in to different subsets including memory T cells

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3
Q

What is the immune system source and the principle effects of IL-3

A

T-cells

effects: Stimulates and leads to maturation of multiple immature hematopoietic cell lineages

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4
Q

What is the immune system source and the principle effects of IL-4

A

Th2-Cells

effects: Isotype switching to IgE upon stimulation of B-cells; Increased Th2 cellular proliferation and differentitation

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5
Q

What is the immune system source and the principle effects of IL-5

A

Th-2 Cells

effects: Eosinophil Activator, B Cell activation, Increased IgA secretion

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6
Q

What is the immune system source and the principle effects of IL-6

A

T and B cells

Effects: Involved in innate immune response and neutrophil production, B-cell differentiation and induction of acute phase proteins

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7
Q

What is the immune system source and the principle effects of IL-8

A

Monocytes, T-Cells, keratinocytes

effects: Chemokine for neutrophil chemotaxis

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8
Q

What is the immune system source and the principle effects of IL-10

A

Tregs, macrophages

effects: Inhibition of macrophages/dendritic cells and proinflammatory cytokine production; decreased expression of IL-12/Th1 response, costimulatory molecules, and MHC class II

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9
Q

What is the immune system source and the principle effects of IL-12

A

Macrophages, dendritic cells

effects: Activator of Th1 response; Increased interferon-y, TNF-a production; enhances cytotoxic activity of T and NK cells (cell-mediated immunity) composed of p40 and p35 subunits (note: IL-23 also has p40 subunit but is paired with p19)

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10
Q

What is the immune system source and the principle effects of IL-15

A

Monocytes

effects: Proliferation of T and NK cells, enhance survival of memory T cells

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11
Q

What is the immune system source and the principle effects of IL-17

A

Th17 Cells

Effects: Increased cytokine and chemokine production of keratinocytes and macrophages –> key role in psoriasis pathogenesis

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12
Q

What is the immune system source and the principle effects of IL-18

A

Macrophages

effects: Induces IFN-y production and NK-cell proliferation

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13
Q

What is the immune system source and the principle effects of IL-22

A

Th2 cells, Th17 Cells

effects: Activation and proliferation of B-cells; proliferation of Th-17 cells; stimulation of NK Cells

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14
Q

What is the immune system source and the principle effects of IL-23

A

dendritic cells, macrophages

effects: Promotes Th17 proliferation and differentiation –> key role in psoriasis pathogenesis; composed of p40 and p19 subunits (note: IL-12 also has P40 subunit but is paired with P35)

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15
Q

What is the immune system source and the principle effects of TNF-a

A

Macrophages, mast cells, and lymphocytes

effects: activation of macrophages and T and B lymphocytes, Increased proinflammatory cytokine production, leukocyte/endothelial cell adhesion, cachexia, pyrexia, induction of acute phase proteins, Increase MHC class I expression, NK-cell activation

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16
Q

What is the immune system source and the principle effects of IFN-b

A

Fibroblasts, plasmacytoid, dendritic cell

effects; Increased MHC class I expression, antiviral/antitumor state (antiproliferative)

17
Q

What is the immune system source and the principle effects of IFN-y

A

T-cells, NK cells

effects: MHC class I and II induction , macrophage activation and cytokine synthesis., increased ednogthelieal cell/lymphocyte adhesion, antiviral state, antiproliferative (Th1 Cells) Diffentaitation of Th1 Cells, isotope switching with opsonization activity , macrophage activation, increased MHC I/II expression; downregulation of Th2 Pathway

18
Q

What is the immune system source and the principle effects of G-CSF

A

macrophages

effects: stimulates division and differentiation

19
Q

What is the immune system source and the principle effects of GM-CSF

A

T-cells, macrophages

effects: proliferation of granulocytes and macrophage precursor and activators

Alikhan Review of Dermatology (1 decks)

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