Cytokines Flashcards
IL-1
Activation of leukocytes/endothelial cells, induction of fever and acute phase proteins.
IL-1 receptor agonist
Inhibitor of IL-1, switch-off signal for inflammation
IL-6
Induction of acute phase response/B cell growth factor
IL-8
Neutrophil chemoattractant
Chemokines
Chemoattractants for leukocyte populations to sites of inflammation
IL-10
Macrophage deactivator
IL-12
Innate immunity: Inducer of INFγ
Adaptive immunity: Th1 differentiation factor
IL-13
Macrophage deactivator
IL-15
NK and T cell activator
IL-18
IL-1-like cytokine inducing IFNγ
TNFα
Activation of leukocytes/endothelial cells, induction of inflammation and fever.
INFγ
Innate immunity: Macrophage activator
Adaptive immunity: macrophage activation factor
IL-2
Lymphocyte growth factor (adaptive immunity)
IL-4
Th2 differentiation factor (adaptive immunity)
IL-5
B cell growth factor
