Cytokines Flashcards
IL-2
Source: T cells Targets: T cell-->proliferation B cells-->proliferation (also may contributes to Ab synthesis) NK cells-->proliferation, activation
IL-3
Source: T cells
Targets:
Hematopoetic stem cells–>proliferation, differentiation
IL-4
Source: Th2 cells, mast cells
Target: B cell–>proliferation, isotype switching to IgG, IgE
IL-5
Source: Th2 cells, mast cells
Targets:
B cells–>proliferation, isotype switching to IgA
Eosinophils–>proliferation
IL-6
Source: APCs, Th2 cells, endothelial cells
Targets:
Liver–>acute phase protein synthesis
B cells–>increased antibody production
IL-7
Source: Thymic stroma, marrow stroma
Target: Hemopoetic cells–>T and B cell lymphopoeisis
IL-8
Source: macrophages, PMNs, NK cells
Targets:
PMNs–>recruitment, degranulation
T cells–>recruitment
IL-10
Source: CTLs, Th2 cells, B cells, macrophages
Targets:
B cells–>proliferation, Ab production
IL-12
Source: APCs Targets: Promotes cellular immunity T cells-->Th1 differentiation, TNF-y synthesis NK cells-->activation, y-INF synthesis
IL-13
Source: Th2 cells Targets: B cells-->isotype swithcing to IgE Epithelial cells-->mucus production Macrophages-->inhibition
IL-15
Source: Macrophages
Targets: NK cells–> proliferation
CTLs–>proliferation
IL-18
Source macrophages
Targets:
NK cells–>INF-y synthesis
TH1 cells–>INF-y synthesis
a-INF, B-INF
Source: Macrophages, PMNs, fibroblasts
Targets:
All cells–>antiviral state with increase of MHC-I expression
NK cells–>activation
y-INF
Source: Th1 cells, NK cells
Targets: APCs–>increase MHC-I and MHC-II expression
All cells–>increased MHC-I expression and increased ag presentation
TNF alpha (cachetin)
Source: Dendritic cells
Targets: dendritic cells–>maturation, micration to lymph nodes
T cells–>increased synthesis of IL-2 receptors
B cells–>proliferation
PMNs–>recruitment, activation
