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Cytokines > Cytokines > Flashcards

Cytokines Flashcards

1
Q

IL-1(Produced by & Effect)

A

Produced by: MacrophageEffect: Inflammation, activate lymphocytes, fever

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2
Q

IL-2(Produced by & Effect)

A

Produced by: T cellsEffect: T-cell proliferation, Ig synthesis by B cells, increase NK activity

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3
Q

IL-3(Produced by & Effect)

A

Produced by Th1Effect: Growth and differentiation of hematopoeitic cells

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4
Q

IL-4(Produced by & Effect)

A

Produced by: Th2, mast cells, basophilsEffect: Differentiation of Th2 cells; activation of N cell, class switch to IgG2, 4, A, E; T cell growth factor

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5
Q

IL-5(Produced by & Effect)

A

Produced by: Th2Effect: B cell differentiation, influences class switch

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6
Q

IL-6(Produced by & Effect)

A

Produced by: Th2, macrophageEffect: Activate T & B lymphocyte differentiation; fever; acute phase proteins from liver

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7
Q

IL-7(Produced by & Effect)

A

Produced by: stromal cellsEffect: B and T development in marrow; T cell growth factor; survival signal for memory T

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8
Q

IL-8(Produced by & Effect)

A

same as CXCL8Produced by: macrophageEffect: chemotaxis of neutrophils to site of infection

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9
Q

IL-10(Produced by & Effect)

A

Produced by: Regulatory T cells, Th2, macrophagesEffect: Suppression; Interfere with Th1 differentiation

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10
Q

IL-12(Produced by & Effect)

A

Produced by: macrophages, dendritic cellsEffect: Activate NK cells, differentiation of Th1 cells

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11
Q

IL-15(Produced by & Effect)

A

Produced by: many non-T cellsEffect: T cell growth factor; survival signal for memory T cells

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12
Q

IL-17(Produced by & Effect)

A

Produced by: Th17Effect: Binds to many cell types to induce inflammation

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13
Q

IL-23(Produced by & Effect)

A

Produced by: innate immune cellsEffect: Differentiation of Th17 cells

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14
Q

TNF (TNF-alpha)(Produced by & Effect)

A

Produced by: Macrophage, Th1Effect: Inflammation; increase permeability and activate vascular endothelium; dendritic cells to 2ndary lymphoid tissue; fever; mobilize metabolites; mobilize neutrophils

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15
Q

LT-alpha (TNF-beta)(Produced by & Effect)

A

Produced by: Th1Effect: Activate endothelium to attract macrophages to site

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16
Q

CD40 Ligand(Produced by & Effect)

A

Produced by: T cellEffect: Activate B cells to make antibody; activate macrophage to kill intracellular pathogens

17
Q

Fas Ligand(Produced by & Effect)

A

Produced by: T cellEffect: Apoptosis following immune response and during T cell development

18
Q

IFN-alpha (Type I)(Produced by & Effect)

A

Produced by: any cell infected by virusEffect: Increase resistance to viral infection; increase susceptibility to killing via ag presentation; activate NK cells

19
Q

IFN-beta (Type I)(Produced by & Effect)

A

Produced by: Any cell infected by virusEffect: Increase resistance to viral infection; increase susceptibility to killing via ag presentation; activate NK cells

20
Q

IFN-gamma (Type II)(Produced by & Effect)

A

Produced by: Th1, cytotxic T, NKEffect: Activate macrophage to kill intracellular pathogen; increase resistance to viral infection; increase susceptibility to killing via ag presentation; differentiation of Th1 cells; interfere with Th2 differentiation; class switch to IgG1

21
Q

G-CSF(Produced by & Effect)

A

Colony-Stimulating FactorProduced by: Fibroblasts, monocytesEffect: Neutrophil development in marrow

22
Q

M-CSF(Produced by & Effect)

A

Effect: Monocyte development and differentiation in marrow

23
Q

GM-CSF

A

Produced by: T cells, macrophagesEffect: Granulocyte and monocyte differentiation in marrow

24
Q

SCF (Stem Cell Factor)

A

Produced by: Stromal cellsEffect: B and T development in marrow

25
Q

TGF-beta(Produced by & Effect)

A

Produced by: Regulatory T cell, Th2, monocytes, chondrocytesEffect: Suppression; interfere with Th1 differentiation, class switch to IgG2,4, A, E

26
Q

CXCL8(Produced by & Effect)

A

same as IL-8Produced by: macrophageEffect: chemotaxis of neutrophils to site of infection

27
Q

CCL2(Produced by & Effect)

A

Produced by: Th1Effect: macrophages move to site of infection

28
Q

CCL19/CCL21/CXCL13(Produced by & Effect)

A

Produced by: dendritic cells, stromal cells, HEVEffect: Homing in lymph node of B, T dendritic cells

Cytokines (2 decks)

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