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Host Defense > Cytokines > Flashcards

Cytokines Flashcards

1
Q

Main cell source of: IFN-γ

A

Th1, NK and NKT cells

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2
Q

Main cell source of: IL1

A

Monocytes and activated macrophages

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3
Q

Main cell source of: IL2

A

Th1 Cells

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4
Q

Main cell source of: IL4

A

TH2 Cells

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5
Q

Main cell source of: IL6

A

Monocytes and activated macrophages

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6
Q

Main cell source of: IL8

A

Monocytes and activated macrophages

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7
Q

Main cell source of: IL10

A

Dendritic cells, Monocytes and activated macrophages, Th2 and Tregs

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8
Q

Main cell source of: IL12

A

Monocytes and activated macrophages, Dendritic cells

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9
Q

Main cell source of: IL21

A

Th1, Th2 and Th17

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10
Q

Main cell source of: IL23

A

Dendritic cells, Monocytes and activated macrophages

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11
Q

Main cell source of: TNF-α

A

Dendritic cells, Monocytes and activated macrophages

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12
Q

Main cell source of: TGF-β

A

Many cells

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13
Q

Major function of: IFN-γ

A

TMMI, inhibits Th17

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14
Q

Major function of: IL1

A

Pro-inflammatory

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15
Q

Major function of: IL2

A

T cell proliferation, Treg survival

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16
Q

Major function of: IL4

A

Antibody immunity, inhibit Th17

17
Q

Major function of: IL6

A

Innate immunity, B cell growth, induction of Th17

18
Q

Major function of: IL8

A

Pro-inflammatory, major neutrophil chemokine

19
Q

Major function of: IL10

A

Suppression of some inflammatory pathways

20
Q

Major function of: IL12

A

Induction of Th1

21
Q

Major function of: IL21

A

Proliferation of Th1, Th2 and Th17

22
Q

Major function of: IL23

A

Th17 expansion and stabilization

23
Q

Major function of: TNF-α

A

Pro-inflammatory

24
Q

Major function of: TGF-β

A

Induction of Tregs of Th17

Host Defense (3 decks)

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