cytokines

Question 1

which cells produce IL-1 (alpha, beta)

Answer 1

macrophage, endothelial, dendritic, langerhans

Question 2

what functions do IL-1 (alpha, beta) have?

Answer 2

• stimulates IL-2 receptor emergence in T cells
• enhances B cell activation
• induces fever/IL-6

Question 3

which cells produce IL-2?

Answer 3

Th1

Question 4

what functions does IL-2 have?

Answer 4

• T cell growth factor

- activates NK and B cells

Question 5

which cells produce IL-3?

Answer 5

T cells

Question 6

what does IL-3 do?

Answer 6

stimulates hematopoiesis

Question 7

which cells produce IL-4?

Answer 7

T cells

Question 8

what does IL-4 do?

Answer 8

• stimulates synthesis of IgE

- down regulates IFN-g

Question 9

what cells produce IL-5?

Answer 9

T cells

Question 10

what does IL-5 do?

Answer 10

• stimulates growth and differentiation of eosinophils
• B cell growth factor
• enhances IgA synthesis

Question 11

which cells produce IL-6?

Answer 11

monocytes, T cells, endothelial cells

Question 12

what does IL-6 do?

Answer 12

induces fever and late B cell differentiation

Question 13

which cells produce IL-7?

Answer 13

bone marrow cells

Question 14

what does IL-7 do?

Answer 14

stimulates pre B and pre T cells

Question 15

which cells produce IL-8?

Answer 15

monocytes, endothelial cells, lymphocytes, fibroblasts

Question 16

what does IL-8 do?

Answer 16

chemotactic factor for neutrophils and T cells

Question 17

which cells produce IL-9?

Answer 17

Th cells

Question 18

what does IL-9 do?

Answer 18

T cell migration

Question 19

what cells produce IL-10?

Answer 19

Th2 cells

Question 20

what does IL-10 do?

Answer 20

• inhibits IFN-g synthesis by Th1 cells

- cytokine suppressor

Question 21

what cells produce IL-11?

Answer 21

bone marrow

Question 22

what does IL-11 do?

Answer 22

stimulates hematopoesis

Question 23

what cells produce IL-12?

Answer 23

macrophages and B cells

Question 24

what does IL-12 do?

Answer 24

• promotes Th1 differentiation and IFN-g synthesis
• stimulates NK cells and CD8+ cells
• works with IL-2

Question 25

which cells produce IL-13?

Answer 25

Th2 cells

Question 26

what does IL-13 do?

Answer 26

inhibits inflammatory cytokines (1, 6, 8, 10, MCP)

Question 27

which cells produce IL-15?

Answer 27

T cells

Question 28

what does IL-15 do?

Answer 28

• T cell mitogen

- enhances growth of intestinal endothelium

Question 29

what cells produce IL-16?

Answer 29

CD8+ cells, eosinophils

Question 30

what does IL-16 do?

Answer 30

• increases class II MHC, chemotaxis, and CD4+ cytokines

- decreases antigen induced proliferation

Question 31

what cells produce IL-17?

Answer 31

T cells

Question 32

what does IL-17 do?

Answer 32

enhances inflammatory response

Question 33

what cells produce IL-18?

Answer 33

activated macrophages

Question 34

what does IL-18 do?

Answer 34

increases IFN-g production and NK cells

Question 35

what cells produce TNF-a?

Answer 35

macrophages, T cells, B cells, large granular lymphocytes

Question 36

what does TNF-a do?

Answer 36

• cytotoxic for tumors
• causes cachexia
• mediates bacterial shock

Question 37

what cells produce TNF-b?

Answer 37

T cells

Question 38

what does TNF-b do?

Answer 38

cytotoxic for tumors

Question 39

what cells produce transforming growth factor B?

Answer 39

almost all normal cells

Question 40

what does TGF-b do?

Answer 40

• inhibits proliferation of B and T cells
• reduces cytokine receptors
• potent chemotactic agent for leukocytes
• mediates inflammation and tissue repair