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Serology > Cytokines > Flashcards

Cytokines Flashcards

0
Q

Regulates immune system

A

Cytokines

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1
Q

Generic term for soluble mediators

A

Cytokines

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2
Q

Major cytokines

A 
Interleukins
Interferons
Tumor necrosis factors
Chemokines
Transforming growth factors(tgf)
Colony stimulating factors(csf)
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3
Q

Il1

A

Endogenous pyrogen

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4
Q

Il2

A

T cell growth factor

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5
Q

Il6

A

Stimulates b cells

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6
Q

Are protein produce by virally infected cells andprotect the neighboringcells

A

Interferon

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7
Q

Exert a virus nonspecific but host specific anti viral activity

A

Interferon

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8
Q

Type of interferinwhich is non specific

A

Type i

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9
Q

Type of interferon which is specific

A

Type ii

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10
Q

What type of if produces alphaand beta

A

Type i
Alpha- leukocyte
Beta-fibroblast

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11
Q

What type of if produces gamma

A

Type ii

Gamma- t cells

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12
Q

Cytotoxic activity agains dtumor cells and virally infected cells

A

Tnf

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13
Q

Tnf that is produced by the macrophage

A

Alpha tnf

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14
Q

Other term for aloha tnf

A

Cachetin

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15
Q

Tnf that is produced by cd41 and cd8

A

Beta tnf

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16
Q

Other term for beta tnf

A

Lymphotoxin

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17
Q

Enhances motility and promote migration of wbc

A

Chemokines

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18
Q

Release by platelets during coagulation

A

Betalysin

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19
Q

Betalysin

A

3,6 -diaminohexanoic acid

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20
Q

A set of proteins that play a role in cytolitic destruction of cellular antigens by specific antibody

A

Complement system

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21
Q

Complements the antibody

A

Cell lysis promition

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22
Q

Serum

Inactivation

A

Removal of complement proteins

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23
Q

2 ways to inactivate serum

A

Physical- 56*c for 30 mins

Chemical- CHOLINE CHLORIDE

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24
Q

Chemotaxin

A

C5a c5b c6 c7

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25
Q

Immune adherence

A

C3b

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26
Q

Kinin activator

A

C2b

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27
Q

Anaphylotoxin

A

C3a c4a C5A(most potent)

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28
Q

Opsonins

A

C3b c4b c5bm

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29
Q

A- smAller
B-Bigger
Except

A

C2a

C2b

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30
Q

Heaviest

A

C1q

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31
Q

Binds q r s

A

Calcium

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32
Q

Most abundant

A

C3

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33
Q

Synthesize in the intestinal epithelial cell

A

C1

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34
Q

Synthesize in the adipose

A

Factor d

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35
Q

Mbl

A

Mannose binding lectin

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36
Q

Classical pathway is initiated by

A

2 igg and 1 igm

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37
Q

Recognition unit in classical pathway

A

C1

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38
Q

Activation unit in classical pathway

A

C4,2,3

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39
Q

Membrane attack complex of classical pathway

A

C5-9

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40
Q

Recognition unit of the alternative pathway

A 
Bacterial cell wall 
Fungal cell wall
Yeast
Viruses
Virally infected cells
Tumor cell line
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41
Q

Hstabilizes the c3 convertsse

A

Properdin

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42
Q

Mg dependent

A

Alternative pathway

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43
Q

Activation unit of lectin pathway

A

C5 convertase c3b4b2a

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44
Q

Membrane attack complex of lectin pathway

A

C5-9

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45
Q

Dissociates c1r and s from c1q

A

C1 inhibitor c1inh

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46
Q

Cleaves c3b and c4b

A

Factor I

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47
Q

Prevents binding of b to c3b

A

Factor h

48
Q

Cofactor with I to inactivate c3b

A

Factor h

49
Q

Acts as cofactor with i to inactivate c4b

A

C4 binding prot

50
Q

Prevents attachment of the c6b67 complex to cell membranes

A

S proteins(vitronectin)

51
Q

Inhibits activationat the first stages of both classical and lectin pathway

A

C1 inhibitor

52
Q

Four main regulators thaat inhibit the formation of c3 convertase

A

C4 binding protein
Complement receptor type 1
Membrane cofactor protein
Decay accelerating factor

53
Q

The ability of cells to bind complement coated particles

A

Immune adherence

54
Q

Inhibitors of mac

A

Homologous restriction factor

Membrane inhibitor of reactive lysis

55
Q

Cd59

A

Membrane inhibitor of reactive lysis

56
Q

Amount
Of complement protein serum
That can cause hemolysis of the 50% of a standardized concentration of antibody-sensitized sheep rbc

A

Ch50 assay

57
Q

Small peptide that causes increased vascular permeability, contraction of smooth muscle and release of histmine from
Basophiles and mast cells

A

Anaphylatoxin

58
Q

Assoc disease for c1

A

L recurrent infec

59
Q

Assoc disease forc2

A

L recurrent infect

Atherosclerosis

60
Q

Assoc disease forc3

A

Severe rec inf

Glomerulonephritis

61
Q

Assoc disease forc4

A

L

62
Q

C5-c8

A

Neisseria inf

63
Q

C1inh Assoc disease for

A

Hereditary angioedema

64
Q

Assoc disease for daf mirl

A

Pnh paroxysmal nocturnal hemoglobinuria

65
Q

factor h and i

A

Recurrent pyogenic infection

66
Q

Assoc disease for mbl masp 2

A

Pneumococcla disease

67
Q

Assoc disease for properdin

A

Neisseria infection

68
Q

Elevated complement components

A

Have little clinical importance

69
Q

Decreased complement components

A

Complement is currently being consumed

May be decreased or absent due to genetic defect

70
Q

2 systems involved for complement fixation

A

Test system/ bacteriolytic sys

Indicator sys/ hemolytic sys

71
Q

Positive result for complementfixation

A

Red cells notlysee

72
Q

Reporting in complementfixation

A

Highest dilutionsharingno hemolysis

73
Q

Initialforce of attractionbetween single fab and single epitope

A

Affinity

74
Q

Affinity ex

A

Ionic bond
Hydrogen bond
Hydrophobic bond
Van der waals forces

75
Q

Sum of all attractive forces between an antigen and antibody

A

Avidity

76
Q

Primary response

A

Longer lag
Lower ab
Igm

77
Q

Secondary response

A

Shorter lag
Higher ab
Igg

78
Q

Heightened state of immuneresponsiveness

A

Hypersensitivity reaction

79
Q

In vivo for hypersensitivity

A

Cutaneous

Intradermal test

80
Q

In bitro

A

Total ige
Radioimmunosorbent test
Radioallergosorbent test

81
Q

Type 2 hypersensitivity

A

Transfusion reaction
Hemolytic disease of the newborn
Autoimmune hemolytic anemia

82
Q

Type 3

A

Arthrus reaction
Serum sickness
Autoimmune disease

83
Q

Type 4

A

Contact dermatitis
Hypersensitivity pneumonitis
Tuberculin type hypersensitivity

84
Q

Autoimmune disorders

A

Horror autotoxicus

85
Q

Individual viral or bacterial agents contains ag taht closely resemble self ag

A

Molecular mimicry

86
Q

Examples of molecular mimicry

A

Polio virus vp2 - acetylcholine
Measles virus d3-myelin basic protein
Papilloma virus vp2- insulin receptor

87
Q

General signs of autoimmune disease

A

Presence of diverse ab
Depressed levels of serum compements
Immune complexes in serum
Decreased ts cell

88
Q

Immune complex disease characterized by overproduction of autoantibodies
Manifests itself by skin lesions
Butterfly rash red wolf

A

Systemic lupus erythematosus

89
Q

Lab obs for sle

A

Presence of antinuclear ab
Anti- ds dna
Anti histone ab
Anti-smith ab

90
Q

Appearance le cells

A

Pmn leukocyte with ingested le body often in rosette formation

91
Q

Serologic tests for sle

A

Fluorescent antinuclear antibody-indirect immunofluorescence
Immunodiffusion
Immunoblotting

92
Q

Autoimmune disease causing chronic inflammation of joints and perisrticular tissue

A

Rheumatoid arthritis

93
Q

Group of immunoglobulins that interacts specifically with the fc portion of igg mol

A

Rheumatoid factor

94
Q

Marker for rheumatoid arthritis

A

Anti cyclic citrullinated peptides

95
Q

Lab tests for ra

A

Sheep cell agglutination

Latex fixation test

96
Q

Lymphoma

A

Secondary lymphoid organs

97
Q

Leukemia

A

Bone marrow

98
Q

Plasma cell dyscasia

A

Prolemswithin the plasma cell

99
Q

Presence of reed sternberg cell

A

Lymphoma

100
Q

Reed sternberg is found in

A

T cell lineage

101
Q

Binucleated cell found in the secondary lymphoid organs

A

Reed sternberg cell

102
Q

Owls eye appearnce

A

Reed sternberg cell

103
Q

Classical hodgkin lymphoma

A

Cd13 pos

Cd20 neg

104
Q

Sclerotic lympho predo

A

Cd20 pos
Cd15
Cd18

105
Q

Agent of infectious mononucleosis

A

Virus hodgkins

106
Q

Lymphoblastic

A

Acute-treatable

Chronic- non treatable

107
Q

Presence of poorly defferentiated precursor cells

Coomon among CHILDREN 2-10 yrs old

A

Lymphoblastic anemia

108
Q

Shift to the left

A

Young

109
Q

Shift to the right

A

Mature

110
Q

Common cancer for old

A

Small lymphocytic leukemia

111
Q

B cell origin diseases

A

Chronic lymphocytic leukemia
Prolymphocytic anemia
Small lymphocytic anemihairy cell leukemia

112
Q

Test to distinguish hairy cell leukemia

A

Tartate resistance acid phosphatase

113
Q

Overproduction of single immunoglobulin

A

Plasma cell dyscrasia

114
Q

Most serious

Most common plasma cell dyscrasia

A

Multiple

Myleloma

115
Q

Malignancy of mature plasma cell

Non specific nence jones proteins

A

Multiple myeloma

116
Q

Inc in conc m protein

A

Hyperviscosity syndrome

117
Q

Malignant proliferation of igm producing lymphocytes

A

Waldenstorm’s macroglobulinemia

118
Q

Cryoglobuljns 10-20%

A

Waldenstorms macroglobulinemia

Serology (1 decks)

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