Cytokines Flashcards
0
Q
Regulates immune system
A
Cytokines
1
Q
Generic term for soluble mediators
A
Cytokines
2
Q
Major cytokines
A
Interleukins Interferons Tumor necrosis factors Chemokines Transforming growth factors(tgf) Colony stimulating factors(csf)
3
Q
Il1
A
Endogenous pyrogen
4
Q
Il2
A
T cell growth factor
5
Q
Il6
A
Stimulates b cells
6
Q
Are protein produce by virally infected cells andprotect the neighboringcells
A
Interferon
7
Q
Exert a virus nonspecific but host specific anti viral activity
A
Interferon
8
Q
Type of interferinwhich is non specific
A
Type i
9
Q
Type of interferon which is specific
A
Type ii
10
Q
What type of if produces alphaand beta
A
Type i
Alpha- leukocyte
Beta-fibroblast
11
Q
What type of if produces gamma
A
Type ii
Gamma- t cells
12
Q
Cytotoxic activity agains dtumor cells and virally infected cells
A
Tnf
13
Q
Tnf that is produced by the macrophage
A
Alpha tnf
14
Q
Other term for aloha tnf
A
Cachetin
15
Q
Tnf that is produced by cd41 and cd8
A
Beta tnf
16
Q
Other term for beta tnf
A
Lymphotoxin
17
Q
Enhances motility and promote migration of wbc
A
Chemokines
18
Q
Release by platelets during coagulation
A
Betalysin
19
Q
Betalysin
A
3,6 -diaminohexanoic acid
20
Q
A set of proteins that play a role in cytolitic destruction of cellular antigens by specific antibody
A
Complement system
21
Q
Complements the antibody
A
Cell lysis promition
22
Q
Serum
Inactivation
A
Removal of complement proteins
23
Q
2 ways to inactivate serum
A
Physical- 56*c for 30 mins
Chemical- CHOLINE CHLORIDE
24
Chemotaxin
C5a c5b c6 c7
25
Immune adherence
C3b
26
Kinin activator
C2b
27
Anaphylotoxin
C3a c4a C5A(most potent)
28
Opsonins
C3b c4b c5bm
29
A- smAller
B-Bigger
Except
C2a
| C2b
30
Heaviest
C1q
31
Binds q r s
Calcium
32
Most abundant
C3
33
Synthesize in the intestinal epithelial cell
C1
34
Synthesize in the adipose
Factor d
35
Mbl
Mannose binding lectin
36
Classical pathway is initiated by
2 igg and 1 igm
37
Recognition unit in classical pathway
C1
38
Activation unit in classical pathway
C4,2,3
39
Membrane attack complex of classical pathway
C5-9
40
Recognition unit of the alternative pathway
```
Bacterial cell wall
Fungal cell wall
Yeast
Viruses
Virally infected cells
Tumor cell line
```
41
Hstabilizes the c3 convertsse
Properdin
42
Mg dependent
Alternative pathway
43
Activation unit of lectin pathway
C5 convertase c3b4b2a
44
Membrane attack complex of lectin pathway
C5-9
45
Dissociates c1r and s from c1q
C1 inhibitor c1inh
46
Cleaves c3b and c4b
Factor I
47
Prevents binding of b to c3b
Factor h
48
Cofactor with I to inactivate c3b
Factor h
49
Acts as cofactor with i to inactivate c4b
C4 binding prot
50
Prevents attachment of the c6b67 complex to cell membranes
S proteins(vitronectin)
51
Inhibits activationat the first stages of both classical and lectin pathway
C1 inhibitor
52
Four main regulators thaat inhibit the formation of c3 convertase
C4 binding protein
Complement receptor type 1
Membrane cofactor protein
Decay accelerating factor
53
The ability of cells to bind complement coated particles
Immune adherence
54
Inhibitors of mac
Homologous restriction factor
| Membrane inhibitor of reactive lysis
55
Cd59
Membrane inhibitor of reactive lysis
56
Amount
Of complement protein serum
That can cause hemolysis of the 50% of a standardized concentration of antibody-sensitized sheep rbc
Ch50 assay
57
Small peptide that causes increased vascular permeability, contraction of smooth muscle and release of histmine from
Basophiles and mast cells
Anaphylatoxin
58
Assoc disease for c1
L recurrent infec
59
Assoc disease forc2
L recurrent infect
| Atherosclerosis
60
Assoc disease forc3
Severe rec inf
| Glomerulonephritis
61
Assoc disease forc4
L
62
C5-c8
Neisseria inf
63
C1inh Assoc disease for
Hereditary angioedema
64
Assoc disease for daf mirl
Pnh paroxysmal nocturnal hemoglobinuria
65
factor h and i
Recurrent pyogenic infection
66
Assoc disease for mbl masp 2
Pneumococcla disease
67
Assoc disease for properdin
Neisseria infection
68
Elevated complement components
Have little clinical importance
69
Decreased complement components
Complement is currently being consumed
| May be decreased or absent due to genetic defect
70
2 systems involved for complement fixation
Test system/ bacteriolytic sys
| Indicator sys/ hemolytic sys
71
Positive result for complementfixation
Red cells notlysee
72
Reporting in complementfixation
Highest dilutionsharingno hemolysis
73
Initialforce of attractionbetween single fab and single epitope
Affinity
74
Affinity ex
Ionic bond
Hydrogen bond
Hydrophobic bond
Van der waals forces
75
Sum of all attractive forces between an antigen and antibody
Avidity
76
Primary response
Longer lag
Lower ab
Igm
77
Secondary response
Shorter lag
Higher ab
Igg
78
Heightened state of immuneresponsiveness
Hypersensitivity reaction
79
In vivo for hypersensitivity
Cutaneous
| Intradermal test
80
In bitro
Total ige
Radioimmunosorbent test
Radioallergosorbent test
81
Type 2 hypersensitivity
Transfusion reaction
Hemolytic disease of the newborn
Autoimmune hemolytic anemia
82
Type 3
Arthrus reaction
Serum sickness
Autoimmune disease
83
Type 4
Contact dermatitis
Hypersensitivity pneumonitis
Tuberculin type hypersensitivity
84
Autoimmune disorders
Horror autotoxicus
85
Individual viral or bacterial agents contains ag taht closely resemble self ag
Molecular mimicry
86
Examples of molecular mimicry
Polio virus vp2 - acetylcholine
Measles virus d3-myelin basic protein
Papilloma virus vp2- insulin receptor
87
General signs of autoimmune disease
Presence of diverse ab
Depressed levels of serum compements
Immune complexes in serum
Decreased ts cell
88
Immune complex disease characterized by overproduction of autoantibodies
Manifests itself by skin lesions
Butterfly rash red wolf
Systemic lupus erythematosus
89
Lab obs for sle
Presence of antinuclear ab
Anti- ds dna
Anti histone ab
Anti-smith ab
90
Appearance le cells
Pmn leukocyte with ingested le body often in rosette formation
91
Serologic tests for sle
Fluorescent antinuclear antibody-indirect immunofluorescence
Immunodiffusion
Immunoblotting
92
Autoimmune disease causing chronic inflammation of joints and perisrticular tissue
Rheumatoid arthritis
93
Group of immunoglobulins that interacts specifically with the fc portion of igg mol
Rheumatoid factor
94
Marker for rheumatoid arthritis
Anti cyclic citrullinated peptides
95
Lab tests for ra
Sheep cell agglutination
| Latex fixation test
96
Lymphoma
Secondary lymphoid organs
97
Leukemia
Bone marrow
98
Plasma cell dyscasia
Prolemswithin the plasma cell
99
Presence of reed sternberg cell
Lymphoma
100
Reed sternberg is found in
T cell lineage
101
Binucleated cell found in the secondary lymphoid organs
Reed sternberg cell
102
Owls eye appearnce
Reed sternberg cell
103
Classical hodgkin lymphoma
Cd13 pos
| Cd20 neg
104
Sclerotic lympho predo
Cd20 pos
Cd15
Cd18
105
Agent of infectious mononucleosis
Virus hodgkins
106
Lymphoblastic
Acute-treatable
| Chronic- non treatable
107
Presence of poorly defferentiated precursor cells
| Coomon among CHILDREN 2-10 yrs old
Lymphoblastic anemia
108
Shift to the left
Young
109
Shift to the right
Mature
110
Common cancer for old
Small lymphocytic leukemia
111
B cell origin diseases
Chronic lymphocytic leukemia
Prolymphocytic anemia
Small lymphocytic anemihairy cell leukemia
112
Test to distinguish hairy cell leukemia
Tartate resistance acid phosphatase
113
Overproduction of single immunoglobulin
Plasma cell dyscrasia
114
Most serious
| Most common plasma cell dyscrasia
Multiple
| Myleloma
115
Malignancy of mature plasma cell
| Non specific nence jones proteins
Multiple myeloma
116
Inc in conc m protein
Hyperviscosity syndrome
117
Malignant proliferation of igm producing lymphocytes
Waldenstorm's macroglobulinemia
118
Cryoglobuljns 10-20%
Waldenstorms macroglobulinemia
