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FM1 - Exam 2 > Cytokines > Flashcards

Cytokines Flashcards

0
Q

IL-2

A

Powerful T cell growth factor (induces proliferation of activated specific T cell population)

Produced by TH1 CD4+ T cells (can act in autocrine manner)

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1
Q

IL-1

A

Partially mediates acute phase inflammatory response by recruiting inflammatory cells and initiating fever

Produced by APC

Promotes TH17

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2
Q

IL-4

A

Induces synthesis of different type of antibody (IgE) from B cells

Produced by TH2 CD4+ T cells (TH2 pathway)

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3
Q

IL-5

A

Activation of eosinophils

Produced by TH2 CD4+ T cells

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4
Q

IL-6

A

Promote acute phase inflammatory response

Promote TH17 pathway

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5
Q

IL-7

A

Produced in bone marrow by stromal cells

Promotes maturation of nearby B cell progenitor cells (paracrine)

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6
Q

IL-8

A

Mast cell activator

Derived from macrophage

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7
Q

IL-10

A

Inhibitory cytokine released by regulatory T cells (CD4+ T cells with CD25)

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8
Q

IL-12

A

Promotes TH1 pathway

Produced by APC (usually macrophage in TH1 pathway) on initial antigen presentation

Secretion from macrophages induced by IFN-gamma

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9
Q

IL-13

A

Promotes IgE production (type 1 hypersensitivity)

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10
Q

IL-15

A

Activates NK cells

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11
Q

IL-17

A

Secreted by TH17 CD4+ T cells

Promotes TH17 pathway (recruit neutrophils/monocytes)

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12
Q

IL-23

A

Secreted by APC

Promotes TH17 pathway

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13
Q

TNF

A

Acute phase inflammatory response

Acts on/activates neutrophils/endothelial cells

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14
Q

IFN-gamma

A

Activates macrophages, augments phagocytosis and killing of microbes, increase class II expression for more antigen presentation, induces secretion of IL-12

Mediates DTH

Released from TH1 CD4+ T cells (paracrine)

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15
Q

C-C (cys-cys)

A

Attracts monocytes/lymphocytes (NOT neutrophils)

Produced by T cells

16
Q

C-X-C

A

Activation and chemotaxis of neutrophils

Produced by macrophages and endothelial cells

17
Q

G-CSF

A

Granulocyte colony stimulating factor

18
Q

GM-CSF

A

Granulocyte macrophage colony stimulating factor (stimulates both granulocytes and monocytes)

19
Q

TGF-beta

A

Down regulates immune response by delivering inhibitory signals to lymphocytes

Secreted by regulatory CD4+ T cells that have CD25

Stimulates collagen/ECM protein production as part of systemic sclerosis

FM1 - Exam 2 (2 decks)

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