Cytokines Flashcards
IL-1 alpha and beta
- macrophages and epithelial cells
- induces fever, proinflammatory
IL-2
- T cells (naive, Th0, Th1)
- growth factor
IL-4
- Th2, mast cells
- Th2 differentiation, B activation, B switch to IgE
IL-5
- Th2, mast cells
- promotes eosinophelia
IL-6
- Th2, macrophages, endothelial
- T and B growth, acute phase proteins, induce fever
IL-7
- stromal cells
- B and T progenitors
IL-10
- monocytes, T, certain B
- suppress macrophages and CTL, B growth factor
IL-12
- macrophages, dendritic cells
- Th1 differentiation, activates NK
IL-13
- Th2
- B and T growth, acute phase proteins, fever, inhibits macrophages
IL-17
- Th17 T cells
- neutrophil production, proinflammatroy
IL-21
- Th2
- proliferation of B, T, NK
IL-22
- NK, Th17
- acute phase proteins, proinflammatory
IL-23
- DC, mono, macro
- Development and proliferation of Th17
TNF-alpha
- macro, NK, T
- imflammation
Lymphotoxin-alpha
- B and T cells
- apoptosis of target
BAFF (blys)
- B cells
- B cell proliferation, maturation, survival
TGF-beta1
- mono, T, Bsub
- inhibits growth; antiinflammatory; IgA switch
IFN-alpha
- all nucleated
- anti-viral; increases MHC1
IFN-beta
- fibroblasts
- antiviral; increases MHC1
IFN-gamma
- T and NK
- increases macro activation, MHC1 and MHC2 expression, increases Ag processing, Inhibits Th2
