Cytokines Flashcards
1
Q
IL-1 alpha and beta
A
- macrophages and epithelial cells
- induces fever, proinflammatory
2
Q
IL-2
A
- T cells (naive, Th0, Th1)
- growth factor
3
Q
IL-4
A
- Th2, mast cells
- Th2 differentiation, B activation, B switch to IgE
4
Q
IL-5
A
- Th2, mast cells
- promotes eosinophelia
5
Q
IL-6
A
- Th2, macrophages, endothelial
- T and B growth, acute phase proteins, induce fever
6
Q
IL-7
A
- stromal cells
- B and T progenitors
7
Q
IL-10
A
- monocytes, T, certain B
- suppress macrophages and CTL, B growth factor
8
Q
IL-12
A
- macrophages, dendritic cells
- Th1 differentiation, activates NK
9
Q
IL-13
A
- Th2
- B and T growth, acute phase proteins, fever, inhibits macrophages
10
Q
IL-17
A
- Th17 T cells
- neutrophil production, proinflammatroy
11
Q
IL-21
A
- Th2
- proliferation of B, T, NK
12
Q
IL-22
A
- NK, Th17
- acute phase proteins, proinflammatory
13
Q
IL-23
A
- DC, mono, macro
- Development and proliferation of Th17
14
Q
TNF-alpha
A
- macro, NK, T
- imflammation
15
Q
Lymphotoxin-alpha
A
- B and T cells
- apoptosis of target
