Cytokines

Question 1

IL-1(IL-1α, IL-1β) origin

Answer 1

M/M, EN, B, o
Monocyte/ Macrophage, Endothelial cell, B-cell, others.

Question 2

IL-1(IL-1α, IL-1β) function

Answer 2

Lymphocyte activation, macrophage stimulation, fever and acute phase response

Question 3

IL-2 origin

Answer 3

T-cell

Question 4

IL-2 function

Answer 4

Activation and proliferation of T-cells, co-factor in B-cell proliferation

Question 5

IL-4 Origin

Answer 5

T, MA, BA
T-cell, Mast cell, Basophil

Question 6

IL-4 Function

Answer 6

Growth factor for B-cells and Th2 T-cells; inhibits Th1 T-cells; stimulates IgG and IgE production

Question 7

IL-5 Origin

Answer 7

T, MA
T-cell, Mast cell

Question 8

IL-5 function

Answer 8

B-cell growth and antibody production; eosinophil differentiation

Question 9

IL-6 Origin

Answer 9

T, M/M, EN, o
T-cell, Monocyte/ macrophage, endothelial cell, other

Question 10

IL-6 function

Answer 10

T-cell activation; B-cell antibody production; haematopoietic progenitor cell growth; acute phase response

Question 11

IL-8 Origin

Answer 11

M/M, EN, EP, o
Monocyte/ macrophage, endothelial cell, epithelial cell, other

Question 12

IL-8 function

Answer 12

PMN chemoattraction

Question 13

IL-10 origin

Answer 13

M/M, T, o
Monocyte/ macrophage, T-cell, other

Question 14

IL-10 function

Answer 14

Inhibits macrophage cytokine production; inhibits Th1 response, stimulates antibody production

Question 15

IL-12 origin

Answer 15

M/M, B
Monocyte/ macrophage, B-cell

Question 16

IL-12 function

Answer 16

Activates Th1 T-cells and NK cells

Question 17

IFN-α origin

Answer 17

M/M, T, o
Monocyte/ macrophage, T-cell, other

Question 18

IFN-α function

Answer 18

Inhibits RNA viruses; downregulates IL-12; expands memory T-cells; upregulates MHC class I molecules

Question 19

IFN-β origin

Answer 19

EP, F
Epithelial cell, fibroblast

Question 20

IFN-β function

Answer 20

Inhibits RNA viruses; upregulates MHC class I molecules

Question 21

IFN-γ origin

Answer 21

T, NK
T-cell, Natural Killer cell

Question 22

IFN-γ function

Answer 22

Activates macrophages; activates Th1; inhibits Th2 responses

Question 23

TNF-α origin

Answer 23

M/M, T, NK, o
Monocyte/ macrophage, T-cell, Natural Killer cell, other

Question 24

TNF-α function

Answer 24

Activation of macrophages, PMN, endothelial cells; co-factor for B-cell and T-cell proliferation; fever and septic shock

Question 25

TGF-β origin

Answer 25

M/M, T, o
Monocyte/ macrophage, T-cell, other

Question 26

TGF-β function

Answer 26

Downregulates pro-inflammatory cytokines; wound healing

Question 27

Granulocyte-monocyte-stimulating factor origin

Answer 27

T, M/M, EN, F, o
T-cell, Monocyte/ macrophage, endothelial cell, Fibroblast, other

Question 28

Granulocyte-monocyte-stimulating factor function

Answer 28

Growth of PMN and macrophages; enhances function