Cytokines Flashcards
IL-1(IL-1α, IL-1β) origin
M/M, EN, B, o
Monocyte/ Macrophage, Endothelial cell, B-cell, others.
IL-1(IL-1α, IL-1β) function
Lymphocyte activation, macrophage stimulation, fever and acute phase response
IL-2 origin
T-cell
IL-2 function
Activation and proliferation of T-cells, co-factor in B-cell proliferation
IL-4 Origin
T, MA, BA
T-cell, Mast cell, Basophil
IL-4 Function
Growth factor for B-cells and Th2 T-cells; inhibits Th1 T-cells; stimulates IgG and IgE production
IL-5 Origin
T, MA
T-cell, Mast cell
IL-5 function
B-cell growth and antibody production; eosinophil differentiation
IL-6 Origin
T, M/M, EN, o
T-cell, Monocyte/ macrophage, endothelial cell, other
IL-6 function
T-cell activation; B-cell antibody production; haematopoietic progenitor cell growth; acute phase response
IL-8 Origin
M/M, EN, EP, o
Monocyte/ macrophage, endothelial cell, epithelial cell, other
IL-8 function
PMN chemoattraction
IL-10 origin
M/M, T, o
Monocyte/ macrophage, T-cell, other
IL-10 function
Inhibits macrophage cytokine production; inhibits Th1 response, stimulates antibody production
IL-12 origin
M/M, B
Monocyte/ macrophage, B-cell
IL-12 function
Activates Th1 T-cells and NK cells
IFN-α origin
M/M, T, o
Monocyte/ macrophage, T-cell, other
IFN-α function
Inhibits RNA viruses; downregulates IL-12; expands memory T-cells; upregulates MHC class I molecules
IFN-β origin
EP, F
Epithelial cell, fibroblast
IFN-β function
Inhibits RNA viruses; upregulates MHC class I molecules
IFN-γ origin
T, NK
T-cell, Natural Killer cell
IFN-γ function
Activates macrophages; activates Th1; inhibits Th2 responses
TNF-α origin
M/M, T, NK, o
Monocyte/ macrophage, T-cell, Natural Killer cell, other
TNF-α function
Activation of macrophages, PMN, endothelial cells; co-factor for B-cell and T-cell proliferation; fever and septic shock
TGF-β origin
M/M, T, o
Monocyte/ macrophage, T-cell, other
TGF-β function
Downregulates pro-inflammatory cytokines; wound healing
Granulocyte-monocyte-stimulating factor origin
T, M/M, EN, F, o
T-cell, Monocyte/ macrophage, endothelial cell, Fibroblast, other
Granulocyte-monocyte-stimulating factor function
Growth of PMN and macrophages; enhances function
