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IMMUNO SERO > CYTOKINES > Flashcards

CYTOKINES Flashcards

1
Q

Lymphocyte co-stimulation, phagocyte activation,
increase endothelial adhesion molecules

Macrophage, fibroblast, lymphocytes

A

IL-1a

Lymphocytes, macrophage, endothelium

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2
Q

Induces fever and sleep; increased in prostaglandin synthesis

T-cells

A

IL-1β

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3
Q

T-cell growth and activation, NK cell activation, co-stimulates B-cell differentiation

T-cells

A

IL-2

T-cells, B-cells, NK cells

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4
Q

Multi-lineage hematopoietic factor

T-cells, thymic epithelium

A

IL-3

Stem cells

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5
Q

Co-stimulates B-cell differentiation, stimulates MHC class II expression on B-cell and macrophage, promotes class switch, enhances IgG1 and IgE production

Th2 cells, bone marrow stroma

A

IL-4

B-cells

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6
Q

Stimulates in vitro antibody responses, enhances IgA production by stimulated B-cells, stimulates eosinophil differentiation

Th2 cells

A

IL-5

Eosinophils, B-cells

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7
Q

Lymphocyte growth, B-cell differentiation, acute phase protein synthesis

Macrophage, endothelium, Th2 cells

A

IL-6

T-cells, B-cells, hepatocytes

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8
Q

Cell activation

Bone marrow stromal cells

A

IL-7

Pre-B cells, pre-T cells

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9
Q

Stimulates chemotaxis of target cells and stimulates
granulocyte activity

Fibroblasts monocytes, endothelium

A

IL-8

Monocytes, T-cells, neutrophils

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10
Q

Cell division, promotes development

CD4+ T-cells

A

IL-9

T-cells, mast cells

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11
Q

Inhibits cytokine synthesis

Th2 cells

A

IL-10

Th1 cells

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12
Q

Cell division, cell proliferation, and stimulates maturation
of hematopoietic cells

Bone marrow stroma

A

IL-11

Stem cells, plasma cells

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13
Q

Th1 cell development, activation, induces IFN-gamma production from target cells, augments cytotoxic activity of NK cells

B-cells, macrophage

A

IL-12

Th1 cells, NK cells

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14
Q

Division and differentiation, blocks inhibitory monokine
production

Th2 cells

A

IL-13

B-cells, macrophages

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15
Q

Cell proliferation, decreased immunoglobin synthesis

T-cells

A

IL-14

B-cells

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16
Q

Cell division, shares IL-2 bioactivity

Monocytes

A

IL-15

T-cells, B-cells

17
Q

Chemotactic

CD8+ T-cells

A

IL-16

CD4+ T-
cells

18
Q

Pro-inflammatory

T-cells

A

IL-17

Many cells

19
Q

Chemotactic

Macrophage, fibroblast, keratinocytes

A

IL-8 (NAP-1)

T-cells, neutrophils

20
Q

Chemotactic

Macrophage, fibroblast, keratinocytes

A

MCP-1 (MCAF)

Monocytes, memory T-cells

21
Q

Chemoattractant

Macrophage

A

MIP-1α

Monocyte, T-cells, eosinophils

22
Q

Chemoattractant

Macrophage, monocytes, neutrophil, endothelium

A

MIP-1β

CD8+ T-cells

23
Q

Chemoattractant

T-cells, platelets

A

RANTES (Regulated on Activation of T-cells Expressed and Secreted)

Monocytes, memory CD4+ T-cells

24
Q

Cell activation, increased MHC expression

T-cells, NK cells

A

IFN-alpha

Macrophage

25
Q

Anti-viral, increased MHC expression

Leukocytes, T-cell and B-cell, macrophage

A

IFN- gamma

Macrophage

26
Q

Anti-viral, increased MHC expression

Fibroblast

A

IFN-beta

Macrophage

27
Q

Local inflammation, activates and induces NO production

Th1 cells, some Th2 cells, NK cells, macrophage

A

Tumor Necrosis Factor-α (TNF-α)

Macrophage

28
Q

Inhibits B-cell, enhances T-cell killing, activates neutrophil, activates and induces NO production

Th1 cells, some cytotoxic T lymphocytes

A

TNF-β (lymphotoxin)

T-cell, B-cell, macrophage, neutrophil

29
Q

Inhibits activities of T-cell, B-cell and NK cell, activates
neutrophil, promotes matrix formation (wound repair), angiogenesis

T-cells, macrophage, monocyte

A

Transforming Growth Factor (TGF-β)

B-cell, macrophage, NK cell

IMMUNO SERO (1 decks)

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