CYTOKINES Flashcards
Lymphocyte co-stimulation, phagocyte activation,
increase endothelial adhesion molecules
Macrophage, fibroblast, lymphocytes
IL-1a
Lymphocytes, macrophage, endothelium
Induces fever and sleep; increased in prostaglandin synthesis
T-cells
IL-1β
T-cell growth and activation, NK cell activation, co-stimulates B-cell differentiation
T-cells
IL-2
T-cells, B-cells, NK cells
Multi-lineage hematopoietic factor
T-cells, thymic epithelium
IL-3
Stem cells
Co-stimulates B-cell differentiation, stimulates MHC class II expression on B-cell and macrophage, promotes class switch, enhances IgG1 and IgE production
Th2 cells, bone marrow stroma
IL-4
B-cells
Stimulates in vitro antibody responses, enhances IgA production by stimulated B-cells, stimulates eosinophil differentiation
Th2 cells
IL-5
Eosinophils, B-cells
Lymphocyte growth, B-cell differentiation, acute phase protein synthesis
Macrophage, endothelium, Th2 cells
IL-6
T-cells, B-cells, hepatocytes
Cell activation
Bone marrow stromal cells
IL-7
Pre-B cells, pre-T cells
Stimulates chemotaxis of target cells and stimulates
granulocyte activity
Fibroblasts monocytes, endothelium
IL-8
Monocytes, T-cells, neutrophils
Cell division, promotes development
CD4+ T-cells
IL-9
T-cells, mast cells
Inhibits cytokine synthesis
Th2 cells
IL-10
Th1 cells
Cell division, cell proliferation, and stimulates maturation
of hematopoietic cells
Bone marrow stroma
IL-11
Stem cells, plasma cells
Th1 cell development, activation, induces IFN-gamma production from target cells, augments cytotoxic activity of NK cells
B-cells, macrophage
IL-12
Th1 cells, NK cells
Division and differentiation, blocks inhibitory monokine
production
Th2 cells
IL-13
B-cells, macrophages
Cell proliferation, decreased immunoglobin synthesis
T-cells
IL-14
B-cells
Cell division, shares IL-2 bioactivity
Monocytes
IL-15
T-cells, B-cells
Chemotactic
CD8+ T-cells
IL-16
CD4+ T-
cells
Pro-inflammatory
T-cells
IL-17
Many cells
Chemotactic
Macrophage, fibroblast, keratinocytes
IL-8 (NAP-1)
T-cells, neutrophils
Chemotactic
Macrophage, fibroblast, keratinocytes
MCP-1 (MCAF)
Monocytes, memory T-cells
Chemoattractant
Macrophage
MIP-1α
Monocyte, T-cells, eosinophils
Chemoattractant
Macrophage, monocytes, neutrophil, endothelium
MIP-1β
CD8+ T-cells
Chemoattractant
T-cells, platelets
RANTES (Regulated on Activation of T-cells Expressed and Secreted)
Monocytes, memory CD4+ T-cells
Cell activation, increased MHC expression
T-cells, NK cells
IFN-alpha
Macrophage
Anti-viral, increased MHC expression
Leukocytes, T-cell and B-cell, macrophage
IFN- gamma
Macrophage
Anti-viral, increased MHC expression
Fibroblast
IFN-beta
Macrophage
Local inflammation, activates and induces NO production
Th1 cells, some Th2 cells, NK cells, macrophage
Tumor Necrosis Factor-α (TNF-α)
Macrophage
Inhibits B-cell, enhances T-cell killing, activates neutrophil, activates and induces NO production
Th1 cells, some cytotoxic T lymphocytes
TNF-β (lymphotoxin)
T-cell, B-cell, macrophage, neutrophil
Inhibits activities of T-cell, B-cell and NK cell, activates
neutrophil, promotes matrix formation (wound repair), angiogenesis
T-cells, macrophage, monocyte
Transforming Growth Factor (TGF-β)
B-cell, macrophage, NK cell
