Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

SFM Immunology > Cytokines > Flashcards

Cytokines Flashcards

1
Q

Principal cell sources of TNF

A
  • Macrophages
  • T cells
  • Mast Cells
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Cellular targets of TNF & biological effects

A

Proinflammatory (fever, APPs)

  • Arthalgia/myalgia
  • Endothelial cells: activation (inflammation)
  • Neutrophils: activation
  • Many cell types: Apoptosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Principal cell source of IL-1

A
  • Macrophages
  • Dendritic cells
  • Mast cells
  • Endothelial cells
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Cellular targets of IL-1 & biological effects

A

Proinflammatory (fever, induction of APPs)

  • Upregulate expression of adhesion molecules (VCAM1, ICAM1, P/E selectins)
  • Endothelial cells: activation (inflammation)
  • T cells: Th17 differentiation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Principal cell source of chemokines

A
  • Macrophages
  • Dendritic cells
  • T lymphocytes
  • Fibroblasts
  • Endothelial cells
  • Platelets
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Cellular targets of chemokines & biological effects

A
  • Leukocytes (NK cells, T cells, B cells): increased integrin affinity, chemotaxis, activation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Principal cell source of IL-12

A
  • Macrophages

- Dendritic cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Cellular targets of IL-12 & biological effects

A
  • NK cells & T cells: IFN-γ production, increased cytotoxic activity
  • T cells: differentiation of CD4 cell into TH1 cells
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Principal cell source of IFN-γ

A
  • NK cells

- T lymphocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Cellular targets of INF-γ & biological effects

A
  • Activation phagocytosis of macrophages

- Produced by TH1 cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Principal cell source of IFN-α (type 1 IFN)

A
  • Dendritic cells

- Macrophages

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Principal cell source of IFN-β (type 1 IFN)

A
  • Fibroblasts
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Cellular targets of type 1 IFNs & biological effects

A

SECRETED BY INFECTED CELLS/MACROPHAGES

  • Render anti-viral resistance in healthy cells
  • Inhibits viral replication
  • Increased class 1 MHC expression
  • NK cells: activation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Principal cell source of IL-10

A
  • Macrophages
  • Dendritic cells
  • T cells
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Cellular targets of IL-10 & biological effects

A 
Anti-inflammatory
- Macrophages & dendritic cells: inhibition of cytokine and chemokine production, reduced expression of co-stimulants and class 2 MHC molecules
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Principal cell source of IL-6

A
  • Macrophages
  • Mast cells
  • T cells
  • Endothelial cells
17
Q

Cellular targets of IL-6 & biological effects

A

Proinflammatory (fever, APPs)

  • Upregulate expression of adhesion molecules (ICAM1, VCAM1, P/E Selectins)
  • B cells: proliferation of antibody-producing cells
18
Q

Principal cell source of IL-15

A
  • Macrophages
19
Q

Cellular targets of IL-15 & biological effects

A
  • NK cells: proliferation

- T cells: proliferation

20
Q

Principal cell source of IL-18

A
  • Macrophages
21
Q

Cellular targets of IL-18 & biological effects

A
  • NK cells & T cells: IFN-γ synthesis
22
Q

Principal cell source of TNF-β

A
  • Many cell types
23
Q

Cellular targets of TNF-β & biological effects

A
  • Inhibition of inflammation T cells
24
Q

Chemokine that interacts with receptor on neutrophils to induce conformational changes in neutrophils’ LFA-1 and VLA-4 integrins

Chemokine that attracts neutrophils to site of infection

A

IL-8

25
Q

Chemokine that interacts with receptor on monocytes to induce conformational changes in monocytes’ LFA-1 and VLA-4 integrins

Chemokine that attracts monocytes to site of infection

A

MCP-1 (monocyte chemoattractant protein 1)

26
Q

What are the anti-inflammatory cytokines of innate immunity?

A
  • IL-10
  • TNF-β
  • IL-4
  • sIL-IRA (IL-1 receptor antagonist)
27
Q

What are the proinflammatory cytokines?

A
  • IL-6
  • IL-1
  • TNF-α
28
Q

What controls the development of TH2 cells?

A

IL-4

29
Q

What stimulates the proliferation of NK cells?

A

IL-15

30
Q

Principal cell source of IL-2

A

TH1 cells

31
Q

What is the role of IL-2?

A
  • Required for strong proliferation of virus specific CTLs

- Works with INF-α to increase resistance of CTLs to apoptosis

32
Q

What are the 4 cytokines released by macrophages?

A
  • TNF-α
  • IL-1
  • IL-6
  • IL-18
33
Q

What is the result of a transient rise in TNF-α?

A

Shock

34
Q

INF-γ treated macrophages increase the production of:

A
  • Proinflammatory cytokines
  • Reactive oxygen species
  • NO
  • Lysosomal enzymes
35
Q

What stimulates the proliferation of NK cells?

A

IL-15

36
Q

What alters the expression of proteins required for development of B&T Cells? (Stem cell -> Pro B, Stem cell -> Pro T)

A

IL-7

37
Q

What cells secrete IL-7?

A

Thymocytes (immature T cells located in the thymus)

38
Q

Cell that produces proinflammatory cytokines

A

M1 Macrophages

39
Q

Cell that produces anti-inflammatory cytokines

A

M2 Macrophages

SFM Immunology (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions