Cytokines Flashcards
IL-1
Source: Macrophages
Target: Many
Function: Pro-inflammatory, Fever (Hypothalamus), Acute Phase Proteins (Liver)
IL-2
Source: Activated Th cells
Target: Th, Tc, B, NK cells
Function: Proliferation of T, B, NK cells
IL-3
Source: Th, NK cells
Target: Myeloid hematopoietic cells
Function: Myeloid Progenitor cell growth & differentiation
IL-4
Source: Th2, Mast cells
Target: T, B cells
Function: B cell growth & differentiation, Th1 suppression, Th2 differentiation, Class switch to IgE (& IgG)
IL-5
Source: Th2, mast cells
Target: Activated B cells
Function: B cells differentiation to Plasma cells, Eosinophil activation, Class switch to IgA (& IgE)
IL-6
Source: Th2, Th17 cells, Macrophages
Target: T, B cells
Function: Pro-inflammatory, Acute phase reaction protein synthesis (Liver), Th17 differentiation
IL-7
Source: Bone marrow, Thymic stromal cells
Target: Lymphoid stem cells
Function: Growth & differentiation of Lymphoid Progenitor cells, Prolongs naive & memory T cell lifespan
IL-8
Source: Macrophages, epithelial & endothelial cells
Target: Neutrophils
Function: Pro-inflammatory, Chemotaxis of neutrophils
IL-10
Source: Th2, Treg
Target: Macrophages
Function: Anti-inflammatory, suppress Th1 production
IL-12
Source: Macrophages, DC
Target: Tc, NK, Th1 cells
Function: NK cell activation, Th1 differentiation, IFN-gamma pd
IL-13
Source: Th2
Target: B cells
Function: Class switch to IgE
IL-17
Source: Th17
Target: Macrophages
Function: Pro-inflammatory - induce IL-6, IL-1, TNF-alpha; Recruit neutrophils
IL-21
Source: Th17
Target: NK, Tc
Function: Pro-inflammatory
IL-22
Source: Th17
Target: Epithelial cells
Function: Barrier function, Defensins pd
INF-alpha
Source:
Target: DC
Function: Antiviral, increase MHC I expression, NK activation
