Cytogenetics Lecture Flashcards
1
Q
Myeloproliferative neoplasms mutation
A
JAK2 V617F
2
Q
Mastocytosis
A
c-KIT mutation
Resistant to imatinib
3
Q
CML
A
t(9;22)
BCRABL fusion protein
Deregulation of tyrosine kinase
4
Q
Major break point of CML
A
M-BCR p210
5
Q
Minor break point of CML
A
m-BCR p190 (adult ALL)
6
Q
Gleevec mechanism of action
A
Imatinib
Tyrosine kinase inhibitor
7
Q
Mechanism of choice for monitoring CML
A
RT-PCR
8
Q
MDS favorable mutations
A
5q-, 20q-, Y-, TET2 mutation
9
Q
MDS unfavorable mutations
A
7q-, complex
