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Neuropharmacology > Cytochrome P450 system > Flashcards

Cytochrome P450 system Flashcards

1
Q

Which shows most phenotypic variation

A

2D6

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2
Q

Which involved in clozapine metabolism

A

1A2

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3
Q

What does tobacco do to 1A2

A

Induces it

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4
Q

Grapefruit juice - inhibitor to what (2)

A

1A2
3A4

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5
Q

Enzymes located where in cells

A

Endoplasmic reticulum

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6
Q

Inducer or inhibitor: Smoking

A

Inducer

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7
Q

Inducer or inhibitor: Alcohol

A

Inducer

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8
Q

Inducer or inhibitor: Barbiturates (to what)

A

Inducer (1A2, phenobarbital to 3A4)

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9
Q

Inducer or inhibitor: Carbemazepine (to what)

A

Inducer (3A4)

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10
Q

Inducer or inhibitor: St John’s Wort (to what)

A

Inducer (3A4)

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11
Q

Inducer or inhibitor: Phenytoin (to what)

A

Inducer (3A4)

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12
Q

Inducer or inhibitor: Chlorpromazine

A

Inhibitor

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13
Q

Inducer or inhibitor: SSRIs

A

Inhibitor

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14
Q

Inducer or inhibitor: Grapefruit juice

A

Inhibitor

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15
Q

Clozapine
Olanzapine
Asenapine
Agomelatine
Melatonin - substrates to what

A

1A2

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16
Q

Amphetamines
Atomoxetine
Aripiprazole
Clomipramine
Fluoxetine*
Olanzapine
Risperidone
Mianserin
Imipramine
Venlafaxine
Zuclopenthixol - substrates to what

A

2D6

17
Q

Aripiprazole
Clonazepam
Donepazil
Fentanyl
Methadone
Mirtazapine
Quetiapine
Zopiclone - substrates to what

A

3A4

18
Q

Olanzapine - substrate to which 2

A

1A2
2D6

19
Q

Aripiprazole - substrates to which 2

A

2D6
3A4

20
Q

Fluvoxamine inhibits what

A

1A2 (mainly)
(To lesser extent 2D6 and 3A4)

21
Q

Fluoxetine inhibits what (2)

A

2D6
3A4

22
Q

Paroxetine inhibits what (2)

A

2D6
3A4

It is an autoinhibitor at 2D6

23
Q

Bupropion inhibits what

A

2D6

24
Q

Amitriptyline inhibits what

A

2D6

25
Q

Risperidone metabolised by what

A

2D6

26
Q

Zuclopenthixol metabolised by what

A

2D6

27
Q

Quetiapine metabolised by what

A

3A4

28
Q

Mirtazepine metabolised by what

A

3A4

29
Q

Methadone and fentanyl metabolised by what

A

3A4

Neuropharmacology (2 decks)

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