Cytochrome P450 Interactions Flashcards
1
Q
Inducers - reduce the concentration of drugs metabolised by the system
A
C arbamazepine R ifampicin A bArbiturates P Phenytoin S St John's Wort
OUT DRUGS
2
Q
Inhibitors - increase concentration of drugs metabolised by the system
A
Sodium Valproate Ciprofloxacin Sulphonamides Cimetidine / omeprazole Antifungals, amiodarone Isoniazid Erythromycin / clarithromycin Grapefruit juice
3
Q
Substrates - drugs metabolised by the system
A
C Ciclosporin, carbamazepine, citalopram O OCP W Warfarin P Phenytoin, protease inhibitors A Acetylcholinesterase inhibitors (e.g. donepezil) T Theophylline S Statins, steroids
