cysts of the jaws Flashcards
definition
a pathological cavity containing fluid, semi-fluid or gaseous contents and which is not created by the accumulation of pus
sterile fluid - not abscess
can get pus in cysts if infected but not initial cause
how are cysts diverse?
asymptomatic/symptomatic - often asymptomatic unless infected
slow/fast growing
indolent/destructive
are most cysts benign or malignant?
benign
describe usual cyst shape and the reason why
often spherical or egg-shaped
most grow by hydrostatic pressure - accumulation of fluid causes cyst to grow in a certain direction
usual cyst margins
well-defined and corticated
locularity of cysts
often unilocular
can be multilocular (or pseudolocular)
what might multiple cysts indicate?
a syndrome
describe effects cysts can have on surrounding anatomy
displacement of cortical plates, adjacent teeth, MS, IAC
variable degree and pattern of growth - along bone through trabecular bone - get more MD expansion in mandible than BL as dense cortical bone
RR may occur with chronic cysts
what can be included in cysts?
UE teeth
secondary infection
cysts may lose definition and cortication of margins if secondarily infected
typically associated with clinical S+S
classification
structure - epithelial lined vs no epithelial lining
origin - Odontogenic vs non-odontogenic
pathogenesis - developmental vs inflammatory
Odontogenic developmental cysts
dentigerous cyst (+eruption cyst) Odontogenic keratocyst lateral periodontal cyst
Odontogenic inflammatory cysts
radicular (+residual) cyst
inflammatory collateral cysts
- paradental cyst
- buccal bifurcation cyst
non-odontogenic developmental cyst
nasopalatine duct cyst
non-odontogenic other cysts
solitary bone cyst
aneurysmal bone cyst
no epithelial lining
where do Odontogenic cysts occur?
in tooth bearing areas
what is the most common cause of bony swelling in the jaws?
Odontogenic cysts
>90% of all cysts in the oral and MF region
2nd most common group of oral and MF lesions in adults (14-15%)
what are all Odontogenic cysts lined with?
epithelium
Odontogenic sources of epithelium
Rests of Malassez
Rests of Serres
reduced emamel epithelium
epithelial rests get switched on (often by inflammation)
Rests of Malassez
remnants of Hertwig’s epithelial root sheath
Rests of Serres
remnants of the dental lamina
reduced enamel epithelium
remnants of the enamel organ
covers crown of UE tooth then breaks down as tooth erupts
most common Odontogenic cysts
radicular (+residual) - 60%
dentigerous (+ eruption) - 18%
Odontogenic keratocyst - 12%
what type of cyst is a radicular cyst?
inflammatory Odontogenic cyst
what is a radicular cyst always associated with?
a non-vital tooth
cause of a radicular cyst
non-vital tooth
initiated by chronic inflammation at apex of tooth due to pulp necrosis
incidence of radicular cyst
most common in 4th and 5th decade
M=F
60% maxilla, 40% mandible
can involve any tooth
presentation of radicular cyst
often asymptomatic - may become infected - pain
typically slow growing with limited expansion
can produce alveolar bone expansion +/- discharge
what is the only way to confirm if a lesion has progressed to a radicular cyst?
surgically excise
stages of radicular cyst formation
pulpal necrosis
periapical periodontitis
periapical granuloma
radicular cyst
radicular cyst vs periapical granulomas
difficult to differentiate radiographically
- radicular cysts typically larger
if radiolucency diameter >15mm - 2/3 of cases will be radicular cysts
radiographic features of a radicular cyst
well-defined, round/oval radiolucency
corticated margin continuous with lamina dura of non-vital tooth
larger lesions may displace adjacent structures
long-standing lesions may cause external root resorption and/or contain dystrophic calcification
unilocular
uniform radiolucency
histology of radicular cysts
epithelial lining (often incomplete)
- can get ulceration/hyperplasia
- usually non-keratinised SSE 2-10 layers thick
fibrous CT vascular capsule
inflammation in capsule - inflammatory infiltrate
can get cholesterol clefts
growth of a radicular cyst
radicular cyst from granuloma
- Epithelial rests of malassez in PDL become active, divide and proliferate
radicular cysts may form by:
- proliferating epithelium with central necrosis - centre of granuloma cut off from blood supply
- OR epithelium surrounds fluid area
continued growth
- osmotic effect with semi-permeable wall
- cytokine mediated growth - also ILs - activation of osteoclasts
variable inflammation
cholesterol clefts
mucous metaplasia
hyaline/rushton bodies (only in Odontogenic epithelium)
cholesterol clefts
cholesterol in fluid due to rbcs breaking down
may get calcification within cholesterol
variants of a radicular cyst
residual cyst
lateral radicular cyst
residual cyst
when radicular cyst persists after loss of tooth (or after tooth is successfully RCT)
clinical history is important to avoid misdiagnosis
lateral radicular cyst
radicular cyst associated with an accessory canal
located at side of tooth instead of apex
cyst S+S
“egg shell” crackling on palpation - cyst thins cortical bone so when you press it cracks slightly
tingling/altered sensation - presses on nerve
- nasopalatine n (anterior palate)
- IO nerve (side nose, cheek, U lip)
movement/displacement of adjacent teeth
mobility
change in occlusion
sinus involvement - muffling sound, postural changes discomfort
diplopia - v large cyst in maxilla can push up orbital floor
painless swelling of buccal cortex
can get fluctuant swelling if bone completely resorbed
hollow percussion note
what type of cyst is an inflammatory collateral cyst?
inflammatory Odontogenic cyst
what are inflammatory collateral cysts associated with?
a vital tooth
incidence of inflammatory collateral cysts
2-7% of Odontogenic cysts
what is the pouch lined with in inflammatory collateral cysts?
non-keratinised epithelium
what is included in inflammatory collateral cysts?
paradental cyst
buccal bifurcation cyst
where does a paradental cyst typically occur?
distal aspect of PE L8
where does a buccal bifurcation cyst typically occur?
the buccal aspect of L6
roots go lingually, crowns go buccally - affects occlusion
what type of cyst is a dentigerous cyst?
developmental Odontogenic cyst
what are dentigerous cysts associated with?
crown of UE (+ usually impacted) tooth
e.g. L8s, U3s
cystic change of dental follicle
what is a dentigerous cyst the result of?
cystic change of the dental follicle
incidence of dentigerous cysts
most common in 2nd-4th decades
M>F
mandible>maxilla
features of a dentigerous cyst
corticated margins attached to CEJ of tooth (where dental follicle usually attaches)
- larger cysts may begin to envelope root of tooth
- be careful not to misinterpret
may displace involved tooth
tends to be symmetrical initially
- larger cysts may begin to expand unilaterally
variable displacement of cortical bone (i.e. bony expansion)
tooth missing from arch
round/ovoid well-defined unilocular, uniform radiolucency
histology of dentigerous cysts
thin non-keratinised SSE
- may resemble radicular cyst if inflamed
dentigerous cyst vs enlarged follicle
consider cyst if follicular space >4mm
- measure from surface of crown to edge of follicle
- assume cyst if >10mm
consider cyst if radiolucency is asymmetrical
what is an eruption cyst?
variant of dentigerous cyst
contained within ST rather than bone
Rests of Serres
presentation of an eruption cyst
associated with an erupting tooth
more commonly incisors/FPMs
almost exclusive to children
bluish over an erupting tooth
may/may not need intervention - tx conservatively and tooth often erupts
surgical excision of cyst sometimes required
ST
what type of cyst is an Odontogenic keratocyst?
development Odontogenic cyst
does an OK have a relationship to teeth?
no specific one
incidence of OK
most common in 2nd and 3rd decades
M>F
mandible>maxilla (3:1) 70-80% mandible, esp 3rd molar region
posterior>anterior
what was OK previously called?
keratocystic Odontogenic tumour
describe OK margins
often scalloped
what % of OKs are multilocular?
25%
what do OKs often cause of adjacent teeth?
displacement
root resorption uncommon
characteristic expansion of OKs
can enlarge markedly in medullary bone space before displacing cortical bone
i.e. can have significant MD expansion without BL expansion
pre-op diagnostic test - cyst aspirate for OK
contains squames
low soluble protein content: 40g/l (other cysts >50)
histology of OK
corrugated wavy epithelium parakeratosis loss of keratin if inflamed no rete pegs - can detach quite easily basal palisading - nuclei same level epithelium tends to grow in clusters
recurrence of OKs
high recurrence rate (aggressive) - need close monitoring
thin friable lining - difficulty of surgery
daughter/satellite cysts
- small cysts in lining of main cyst
- don’t leave in lining of bone as will grow - recurrence
cell nests (esp retromolar)
presentation of Basal cell naevus syndrome
multiple OKs multiple basal cell carcinomas palmar and plantar pitting calcification of intracranial dura mater skeletal abnormalities - ribs and vertebrae bifid ribs characteristic facial features - frontal and temporal parietal bossing, hypertelorism, mild mandibular prognathism abnormalities of Ca and PO4 metabolism etc
aka Gorlin-Goltz syndrome, bifid rib syndrome
cysts histologically identical to non-syndromic form but often occur at younger age e.g. 15yrs
autosomal dominant trait
non-odontogenic cysts
nasopalatine duct cyst
solitary bone cyst
aneurysmal bone cyst
what is the most common non-odontogenic cyst?
nasopalatine duct cyst
what type of cyst is a nasopalatine duct cyst?
developmental non-odontogenic cyst
what does a nasopalatine duct cyst originate from?
nasopalatine duct epithelial remnants
where does a nasopalatine duct cyst occur?
anterior maxilla
incidence of nasopalatine duct cyst
most common in 4th-6th decades
M>F
presentation of nasopalatine duct cyst
often asymptomatic
pt may note “salty” discharge
larger cysts may displace teeth or cause swelling in palate
always involve midline but not always symmetrical