Cystic Fibrosis

Question 1

Whats the inheritance pattern of CF?

Answer 1

autosomal recessive

Question 2

What causes CF?

Answer 2

a mutation in the CFTR gene on chromosome 7
–>This is a Cl channel, and the defect leads to a combination of defective chloride secretion and increased sodium absorption across airway epithelium. The changes in the composition of airway surface liquid predispose the lung to chronic pulmonary infections and bronchiectasis.