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farmacotherapie 2 > CYP > Flashcards

CYP Flashcards

1
Q

theofylline

A

CYP2A1 substraat

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2
Q

fluvoxamine

A

CYP1A2, CYP2C19 inhibitor

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3
Q

carbamazepine

A

CYP1A2, CYP2C9, CYP3A4 inductor

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4
Q

fenytoïne

A

CYP1A2, CYP2C9, CYP3A4 inductor

CYP2C19, CYP2C9 substraat

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5
Q

rifampicine

A

CYP1A2, CYP2C9, CYP2C19,CYP2D6, CYP3A4, pgp inductor

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6
Q

sigarettenrook

A

CYP1A2 inductor

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7
Q

hypoglycemierende sulfamide

A

CYP2C9 substraat

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8
Q

diazepam

A

CYP2C19 substraat

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9
Q

alprazolam

A

CYP3A4 substraat

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10
Q

zolpidem, zopiclone

A

CYP3A4 substraat

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11
Q

antacida/melk+quinolone

A

complexvorming => gedaalde absorptie

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12
Q

antacida/melk+tetracycline

A

complexvorming => gedaalde absorptie

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13
Q

antacida/melk+Levothyroxine

A

complexvorming => gedaalde absorptie

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14
Q

antacida/melk+bisfosfonaten

A

complexvorming => gedaalde absorptie

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15
Q

antacida+ itraconazole

A

verandering in GI pH=> gedaalde oplosbaarheid/BB

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16
Q

PPI +itraconazole

A

verandering in GI pH=> gedaalde oplosbaarheid/BB

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17
Q

H2 antihistaminica+ itraconazole

A

verandering in GI pH=> gedaalde oplosbaarheid/BB

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18
Q

simvastatine+clarithromycine

A

CYP3A4 subs + CYP3A4 inh

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19
Q

duloxetine

A

SNRI, CYP1A2, CYP2D6 sub+ CYP2D6inh

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20
Q

fenobarbital

A

CYP1A2, CYP2C9, CYP3A4 inductor

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21
Q

dextrometorfan

A

CYP2D6 subs

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22
Q

amitriptyline

A

CYP2D6 subs

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23
Q

haloperidol

A

CYP2D6 subs, QT verlenging

24
Q

paroxetine

A

CYP2D6 subs/inh

25
Q

venlafaxine

A

SNRI, CYP2D6 subs

26
Q

fluconazole

A

CYP2C9 inh

27
Q

miconazole

A

CYP2C9 inh

28
Q

escitalopram

A

SSRI, CYP2C19 subs, QT verlenging

29
Q

terbinafine

A

CYP2D6 inh

30
Q

clarithromycine

A

CYP3A4 inh, QT verlenging

31
Q

erithromycine

A

CYP3A4 inh, QT verlenging

32
Q

telithromycine

A

CYP3A4 inh

33
Q

itraconazole

A

CYP3A4 inh

34
Q

ketoconazole

A

CYP3A4 inh

35
Q

posaconazole

A

CYP3A4 inh

36
Q

voriconazole

A

CYP2C9/CYP3A4 inh

37
Q

digoxine

A

pgp subs

38
Q

st janskruid

A

CYP3A4/pgp inductor

39
Q

loperamide

A

pgp subs

40
Q

risico op hyperkaliëmie

A
  • kalium supplementen
  • GM die aldosteron secretie verminderen: ACE-I, reninine inh, sartanen, NSAID
  • GM die binding aldosteron aan recep inh: spironolactone, canrenoaat, eplerenon
  • GM die renale epithelialen NA kanalen inh: kaliulmsparende diuretica (spironolactin en eplerenon), trimethoprim
41
Q

risico op serotonerg syndroom

A

AD+ antimigraine GM (triptanen, ergotamines)
combo van AD (SSRI, SNRI, MAO inh, lithiumzouten, Sint-jans kruid)
AD+ dextrometorfan
AD+ tramadol, hydromorfon, pethidine

42
Q

pimozide

A

antipsychoticum, QT verlenging

43
Q

sertindol

A

antipsychoticum, QT verlenging

44
Q

droperidol

A

antipsychoticum, QT verlenging

45
Q

flecainide

A

anti aritmicum, QT verlenging

46
Q

sotalol

A

anti aritmicum, QT verlenging, niet selectieve BB

47
Q

amiodaron

A

anti aritmicum, QT verlenging, CYP2C9 inh

48
Q

disopyramide

A

anti aritmicum, QT verlenging

49
Q

moxifloxacine

A

quinolone AB, QT verlenging

50
Q

domperidon

A

QT verlenging, gastroprokineticum

51
Q

carvedilol

A

niet selectieve BB

52
Q

propranolol

A

niet selectieve BB

53
Q

pindolol

A

niet selectieve BB

54
Q

midazolam

A

benzo, CYP3A4 subs

55
Q

triazolam

A

benzo, CYP3A4 subs

56
Q

dexamethasone

A

cortico, CYP3A4 subs

57
Q

omeprazole

A

PPI, CYP2C19 inh

farmacotherapie 2 (6 decks)

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