Cykl kwasu cytrynowego

Question 1

Etap 1 C4 + C2 => C6

Answer 1

Szczawioctan + acetylo-CoA +H2O => Cytrynian + CoA-SH

SYNTAZA CYTRYNIANOWA

Question 2

Etap 2 C6 => C6

Answer 2

Cytrynian => cis-Akonitan + H2O => Izocytrynian

AKONITAZA (HYDRATAZA AKONITANOWA), Fe2+

Question 3

Etap 3 C6 => C5

Answer 3

Izocytrynian + NAD+ => [szczawiobursztynian] + NADH + H+ => alfa-ketoglutaran + CO2 + NADH + H+
DEHYDROGENAZA IZOCYTRYNIANOWA, Mn2+

Question 4

Etap 4 C5 => C4

Answer 4

Alfa-ketoglutaran + NAD+ CoA-SH => bursztynylo-CoA + CO2 + NADH + H+
KOMPLEKS DEHYDROGENAZY ALFA-KETOGLUTARANOWEJ

Question 5

Etap 5 C4 => C4

Answer 5

Bursztynylo-CoA + GDP + Pi => bursztynian + CoA-SH + GTP

SYNTETAZA BURSZTYNYLO-CoA , Mg2+

Question 6

Etap 6 C4 => C4

Answer 6

Bursztynian + FAD => Fumaran + FADH2

DEHYDROGENAZA BURSZTYNIANOWA

Question 7

Etap 7 C4 => C4

Answer 7

Fumaran + H2O => L-jabłczan

FUMARAZA

Question 8

Etap 8 C4 => C4

Answer 8

L-Jabłczan + NAD+ => Szczawioctan + NADH + H+

DEHYDROGENAZA JABŁCZANOWA

Question 9

Suma ATP (jeden obrót)

Answer 9

3NADH + H+ = 3~3ATP = ~9ATP
1FADH2 = ~2ATP
1GTP = ATP
Suma ~12 ATP