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Infectious Disease > Cyclic Peptides > Flashcards

Cyclic Peptides Flashcards

1
Q

Which of the following statements is false?

A. Colistimethate Na is given IM or PO

B. Colistimethate sodium is for the treatment of Cystic Fibrosis

C. Colistimethate forms a salt with diaminobutyrate acid

D. Polymixin B contains the D-Phe while Polymixin E contains D-Leu

A

A. Colistimethane is given IM or INH

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2
Q

The structure shown is Vancomycin. Which of the following statements is false regarding the structure? (select all that apply)

A. The green circle is the glucose

B. the green circle is the vancosamine

C. the blue circle is the glucose

D. the blue circle is the vancosamine

A

A, D

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3
Q

Which of the following is Mupirocin active against? (select all that apply)

A. Streptococcal Infections

B. Staphylococcal Infections

C. MRSA

D. Gram Negative bacteria

A

A, B, C

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4
Q

A patient is on Zocor and needs a cyclic peptide antibiotic. Which of the following should not be recommened because of the ADR: Muscle Pain/ Weakness?

A. Bacitracin

B. Mupirocin

C. Daptomycin

D. Vancomycin

A

C. Daptomycin

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5
Q

Which of the following statement is true about Mupirocin?

A. Has a cyclic structure with a long carbon chain

B. Mechanism of bacterial resistance is frequently the bypass of synthases

C. Metabolism in the skin causes rapid hydrolysis to monic acid, an active metabolite

D. MOA is that it binds to bacterial isoleucine tRNA synthase

A

D. MOA is that it bindsd to bacterial isoleucine tRNA synthase

a is wrong bc its a lipid

b is wrong bc the bypass of synthase is rare

c is wrong bc the monic acid is inactive

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6
Q

Which of the following antibiotics causes an increase in Serum Creatine Phosphokinase?

A. Colistin

B. Bacitracin

C. Vancomycin

D. Daptomycin

A

D. Daptomycin

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7
Q

Which of the following can Daptomycin treat?

A. Gram positive

B. Gram Negative

C. Atypical

D. A and B

A

A. Gram Positive

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8
Q

Which of the following medications cause Nephrotoxicity? (selct all that apply)

A. Vancomycin

B. Bacitracin

C. Colistin

D. Gentamicin

A

A, C, D

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9
Q

What is the antibacterial spectrum for Daptomycin? (select all that apply)

A. Gram Positive

B. MRSA

C. VRE

D. Gram Negative

E. Atypical

A

A, B, C

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10
Q

Which of the following can vancomycin treat?

A. gram positive

B. gram negative

C. atypical

D. A and B

A

A. Gram Positive

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11
Q

Which of the following is the MOA of Daptomycin?

A. inhibits transglycosylase

B. binds to the anionic bacterial outer membrane

C. interferes with the dephosphorylation of the phospholipid carrier

D. binds to the cell membrane and causes depolarization

A

D. Binds to the Cell membrane and causes depolarization

Because of the lipid tail, it inserts into the cell membrane, the insertion into the cell membrane causes potassium ions to come out of the cell therefore causing depolarization.

a is the MOA of vancomycin

b is the MOA Colistin

c is the MOA of bacitracin

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12
Q

Which of the following medications is a metallo-antibiotic?

A. gentamicin

B. Vancomycin

C. Mupirocin

D. Bacitracin

A

D. Bacitracin

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13
Q

True or False

Colistin is not effective against P.aeruginosa

A

Falso

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14
Q

A bacteria increased its lysyl-phosphatidylglycerol synthesis. What drug was a patient taking to cause this bacterial resistance?

A. vancomycin

B. Daptomycin

C. Colistin

D. Mupirocin

A

Daptomycin

Mechanism of Bacterial Resistance is

  1. Cell Wall Thickeining
  2. Increased lysyl-phosphatidylglycerol synthesis in which the cell membrane has phosphate groups and if the bacteria increase the phosphate groups that will cause repulsion of the daptomycin
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15
Q

What happens when I give Atracurium with Colistin?

A. Increased Colistin in the body

B. Increased Neuromuscular Blockade

C. Decreased Neuromuscular Blockade

D. Decreased Colistin in the body

A

B. Increased Neuromuscular Blockade

Remember the Neuromuscular Blocking Agents

Succinylcholine, Vecuronium, Rocuronium…ect

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16
Q

Which antibiotic was given if the bacteria decided to change its lipopolysaccharide layer?

A. Vancomycin

B. Colistin

C. Daptomycin

D. Mupirocin

A

C. Colistin

17
Q

Which of the following are Bacitracin effective against?

A. Gram Positive

B. Gram Negative

C. P. aeruginosa

D. Atypical

A

A. Gram Positive

18
Q

Benny overheard chisme that Luciana was telling Mary Margaret. Luciana told mary Margaret that Benny got redman syndrome because Dr. Scratch-n-sniff gave the following medication too fast. What medication are they talking about?

A. Daptomycin

B. Colistin

C. Vancomycin

D. Bacitracin

A

C. Vancomycin

19
Q

Which of the following MOA and antibiotics is not matched correctly?

A. Vancomycin: inhibits tranglycosylase

B. Bacitracin: binds to the anionic bacterial outer membrane

C. Mupirocin: binds to the bacterial isoleucine tRNA

D. Daptomycin: binds to the cell membrane and causes depolarization

A

B. Bacitracin

Bacitracin interferes with the dephosphorylation of the phospholipid carrier in the cell wall synthesis.

The Phospholipid carrier is a bactoprenol that has to become phosphorylated to pick up a molecule monomer to be transported outside the cell.

20
Q

Which of the following antibiotics is cationic and binds to anionic bacterial outer membranes?

A. Mupirocin

B. Vancoymin

C. Colistin

D. Daptomycin

A

C. Colistin

a binds to the isoleucin tRNA synthase

b inhibits transglycosylase and transpeptidase

d binds to the cell membrane and causes depolarization

21
Q

The cyclic peptides are able to evade the human peptidases, which of the following is a reson they can do it?

A. Cyclic Peptides degrade faster than the linear peptides

B. Cyclic Peptides have a large number of D-amino acids, and the human peptidases can only recognize the D-amino acids.

C. Cyclic Peptidases have unusual number of amino acids

D. Cyclic peptides have a large number of L- amino acids and the human peptidases can only recognize the D-amino acids, therefore they cannot be hydrolyzed

A

C. Cyclic Peptidases have unusual number of amino acids

a is wrong bc cyclic peptidases degrade slower

b. is wrong bc human peptidases only recognize L-amino acids

d is wrong bec cyclic peptidass have a large number of D-amino acids and the human peptidases can only recognize the L-amino acids

22
Q

Which of the following statement is True?

A. Vancomycin, Colistin, and Bacitracin cause Nephrotoxicity

B. Vancomycin and Bacitracin both cause neurotoxicity

C. Colistin and Bacitracin both cause bone marrow toxicity

D. Bacitracin is given orally

A

A. Vancomycin, Colistin, and Bacitracin cause Nephrotoxicity

b is wrong becasue vancomycin causes Red Man’s Syndrome, Nephrotoxicity, and Ototoxicity

c is wrong because Colistin only cause nephrotoxicity and increase in neuromuscular blocked

d is false bc bacitracin is given topically

23
Q

Which of the following is the MOA of Daptomycin?

A. Inhibition of transglycosylate

B. Inhibition of transpeptidase

C. Binds to cell membrane and causes depolorization

D. cationic antibiotic that binds to the anionic bacterial outer membrane

A

C. Binds to cell membrane and causes depolorization

a and b is what vancomycin does

d is what colistin does

24
Q

What is the MOA of Vancomycin? (select all that apply)

a. Prevents the activity of the transglycosylate
b. binds to the 23S rRNA of the 50S subunit
c. Inhibits the transpeptidase function
d. Increases the activity of the transglycosylate

A

A,C

b is the MOA of protein synthesis inhibitors

d is a false statement

25
Q

What bacteria is Colistin effective against?

A. Gram Positive

B. Gram Negative

C. Atypical

D. A and B

A

B.

Infectious Disease (8 decks)

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