CVD Risk Reduction Flashcards

1
Q

What are the non-modifiable risk factors for CVD?

A

Personal history of CVD
Family history of CVD
Age
Gender (women > men)

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2
Q

What are some modifiable risk factors for CVD?

A
Smoking
Alcohol
Hypertension
Dyslipidaemia
Diabetes
Obesity
Physical activity
Thrombogenic factors
Deprivation?
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3
Q

How do you assess someones CVD risk and what is involved?

A

ASSIGN score:

  • age
  • sex
  • smoking
  • systolic BP
  • total cholesterol
  • HDL cholesterol
  • family history of premature CVD
  • diabetes
  • rheumatoid arthritis
  • deprivation
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4
Q

What is the aim of primary prevention?

A

To reduce incidence in a population

before disease

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5
Q

What is the aim of secondary prevention?

A

Detection and treatment of pre-symptomatic disease

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6
Q

What is the aim of tertiary prevention?

A

Reduce incidence/recurrences of chronic incapacity among those with symptomatic disease

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7
Q

What are the SIGN key recommendations for overweight/obesity?

A

Target with interventions, aiming to reduce weight by 3 kg

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8
Q

What is the recommended amount of dietary saturated fat?

A

Men < 30g per day

Women < 20g per day

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9
Q

What is the recommended amount of dietary fish?

A

Twice per week, 1 of which is oily fish

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10
Q

What is the recommended amount of dietary salt?

A

< 6g per day

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11
Q

Which type of diet is recommended for CVD health?

A

Mediterranean

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12
Q

What is the recommended amount of physical activity per week?

A

150 mins moderate exercise OR 75 mins vigorous
Resistance training at least twice per week
Minimise time spent sedentary

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13
Q

Is there a role for anti platelet therapy in primary prevention of CVD?

A

Not recommended for primary prevention

If atherosclerosis –> 75mg aspirin daily

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14
Q

When should lipid lowering drugs be considered for primary prevention of CVD and what should be offered?

A

If at high risk and no evidence of CVD
Offer statin following discussion of risks/benefits
–> Atorvastatin 20mg/day

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15
Q

How might hyperlipidaemia manifest clinically?

A

Xanthomata
Xanthelasma
Corneal arcus
Milky blood/serum

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16
Q

Apart from CVD, what are high triglycerides a risk factor for?

A

Acute pancreatitis

17
Q

How are cholesterol and triglycerides transported in the blood?

A

Lipoproteins e.g. HDL and LDL

18
Q

Which pattern of lipoproteins is associated with CVD?

A

High LDL

Low HDL

19
Q

Which type of cholesterol is ‘bad’ and why?

A

LDL

assist in the production of atheromatous plaques

20
Q

Which cholesterol is ‘good’ and why?

A

HDL

key role in removing excess cholesterol from cells by transporting it to the liver

21
Q

How is cholesterol removed from the body?

A

Only liver has capacity to remove cholesterol from the body

–> secreted into bile or used to synthesise bile salts

22
Q

How do statins work?

A

Inhibit HMG-CoA reductase

–> reduce total and LDL cholesterol

23
Q

How are statins taken?

A

Orally at night

24
Q

What are some side effects of statins?

A

GI upset
Myositis
Rhabdomyolysis (rare)

25
Q

Which drugs are first line for patients with very high triglyceride levels?

A

Fibrates

26
Q

Which other drugs can be given when statin alone does not control cholesterol?

A

Ezetimibe

PCSK9 inhibitors e.g. alirocumab, evolocumab

27
Q

How does Ezetimibe work?

A

Reduces cholesterol absorption in duodenum

28
Q

What are some side effects and contraindications to ezetimibe?

A

SE: diarrhoea, abdominal pain
CI: breastfeeding

29
Q

Which genetic disorder causes high cholesterol and what is its pattern of inheritance?

A

Familial hypercholesterolaemia

Autosomal dominant

30
Q

Which lipid reducing drug and dose should be prescribed for secondary prevention?

A

Atorvastatin 80mg

31
Q

What needs to be checked before starting a statin?

A

LFTs