CV Labs & Diagnostics Flashcards
what is Troponin an indicator of?
most sensitive indicator of myocardial damage
what does troponin differentiate between?
cardiac vs non cardiac chest pain
how long after an MI does a troponin elevate? ___ - ____ hours
when does a troponin level return to baseline? ___ - ____ days
2-3 hours
10-14 days
what is the lab draw schedule for troponin? (3)
initial occurrence, 12 hours, then daily for 3-5 days
What is a CK-MB? ______ found primarily in the ________ _______
What does it help diagnose?
an enzyme found primarily in the heart muscle,
helps to diagnose an acute MI
how long is a CK-MD elevated after an MI? __ hours
when does a CK-MD peak? ___ hours
when does it return to baseline?
3 hours
24 hours
2 days/18-72 hours
between a troponin and a CK-MB which is more specific to cardiac damage?
troponin
What does CRP indicate?
acute or chronic?
specific to heart?
is ESR or CRP more sensitive and quicker?
inflammatory illness
acute
(not specific to heart, could be anywhere in the body)
More sensitive and quicker compared to ESR
NONSPECIFIC
when does a CRP peak?
if a CRP fails to normalize what may it indicate?
18-72 hours
ongoing damage to heart muscle
what CHD issue is CRP not elevated with?
with angina
What is a ESR used for?
acute or chronic?
specific to heart?
is ESR or CRP more sensitive and quicker?
infection, inflammation, or tissue infarction
acute OR chronic infection, chronic inflammation
nonspecific
CRP
how is an ESR useful?
only one that monitors for chronic inflammation
What is a BNP the main source in?
BNP is a _______ released by the __________ in the _______
BNP is a hormone released by the cardiac ventricles in the heart
what does BNP aid in discovering for example with dyspnea?
Elevated BNP = ______ issue (specifically which part?)
Not elevated BNP = ______ issue
distinguishing between cardiac vs. respiratory causes of dyspnea
Elevated BNP = left ventricle dysfunction (cardiac issue)
Not elevated BNP = respiratory issue
when are concentrations higher in a Pro-BNP?
Left ventricular dysfunction
levels are approximately fourfold higher than BNP concentrations
what is the main lipid associated with CV disease?
(higher the ________ = the higher the risk of CAD)
cholesterol
what are the two sources of cholesterol?
endogenous and exogenous
what affects cholesterol?
malnutrition and diurnal variations
what are two types of lipoprotiens?
HDL,LDL
are lipoproteins an accurate predictor of heart disease?
is Cholesterol an accurate predictor of heart disease?
yes
no - Cholesterol is part of a lipid profiling test (not totally accurate predictor of heart disease itself)
what is HDL’s job?
to remove cholesterol
HDL is good cholesterol
What is LDL’s job?
to deposit cholesterol in peripheral tissues
LDL “low down dirty” bad cholesterol
what is a normal cholesterol range?
low risk =
normal =
mod risk =
high risk =
< 200 low risk of CAD
150-200
200-400 mod risk of CAD
>240 high risk of CAD