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Dermatology > Cutaneous drug eruptions > Flashcards

Cutaneous drug eruptions Flashcards

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Dermatology Board Prep flashcards
1
Q

what are the guilty drugs for eruptions

A

NSAIDs, B-lactams, Hapten forming drugs, high molecular weight drugs

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2
Q

List types of drug eruptions

A 
Exanthematous morbilliform maculopapular EMM
Urticarial 
Pustular/bullous 
Fixed 
Severe 
Phototoxic
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3
Q

What is the most common type of drug eruption

A

Exanthametus morbilliform maculopapular rash

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4
Q

How is EMM mediated

A

T cell - delayed type 4 hypersensitivity reaction

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5
Q

How does EMM rash appear

A

widespread symmetrically distributed rash

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6
Q

How are urticarial eruptions mediated

A

IgE or direct mast cell

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7
Q

What might be associated with urticarial eruptions

A

angioedema and/or anaphylaxis

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8
Q

What are the types of pustular/bullous eruptions

A

acneiform
Acute generalised exanthametosis pustulosis
drug induced pemphigoid
linear IgA disease

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9
Q

What drugs cause EMM

A 
penicillins 
sulphonamides 
allopurinol 
NSAIDs
chloramphenicol 
streptomycin 
erythromycin 
phenytoin (anti epileptics)
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10
Q

what drugs cause IgE urticarial eruptions

A

B lactams

Carbamazepine

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11
Q

What drugs cause mast cell urticarial eruptions

A 
aspirin 
NSAIDs
Vancomycin 
opiates 
quinolones 
muscle relaxants
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12
Q

What drugs cause acneiform reactions

A

glucocorticoids
androgens
lithium isoniazid
phenytoin

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13
Q

What drugs cause AGEP

A

CCB
antimalarials
antibiotics

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14
Q

What drug causes linear IgA disease

A

Vancomycin

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15
Q

What drugs cause drug induced pemphigoid

A

ACEI
furosemide
penicillin

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16
Q

What is a fixed drug reaction

A

same painful red well demarcated lesion appears in same place after taking same drug

17
Q

What drugs cause a fixed drug eruption

A

NSAIDs
paracetamol
tetracyclines
carbamazepine

18
Q

Examples of severe cutaneous reactions

A

stevens johnson syndrome SJS
toxic epidermal necrolysis TEN
drug reaction with eosinophilia and systemic symptoms DRESS

19
Q

What appearance occurs with severe eruptions

A 
erythema multiforme 
peeling skin 
mucous membrane involvement 
painful and blistering 
fever

Dermatology (2 decks)

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